A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
GL Amidon, H Lennernäs, VP Shah, JR Crison - Pharmaceutical research, 1995 - Springer
A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution
and in vivo bioavailability is proposed based on recognizing that drug dissolution and …
and in vivo bioavailability is proposed based on recognizing that drug dissolution and …
Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms
JB Dressman, GL Amidon, C Reppas, VP Shah - Pharmaceutical research, 1998 - Springer
Dissolution tests are used for many purposes in the pharmaceutical industry: in the
development of new products, for quality control and, to assist with the determination of …
development of new products, for quality control and, to assist with the determination of …
A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan
…, S Yamashita, LX Yu, GL Amidon - Molecular …, 2006 - ACS Publications
Orally administered, immediate-release (IR) drug products in the top 200 drug product lists
from the United States (US), Great Britain (GB), Spain (ES), and Japan (JP) were provisionally …
from the United States (US), Great Britain (GB), Spain (ES), and Japan (JP) were provisionally …
Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: a mathematical model
DM Oh, RL Curl, GL Amidon - Pharmaceutical research, 1993 - Springer
A microscopic mass balance approach has been developed to predict the fraction dose
absorbed of suspensions of poorly soluble compounds. The mathematical model includes four …
absorbed of suspensions of poorly soluble compounds. The mathematical model includes four …
Gastrointestinal uptake of biodegradable microparticles: effect of particle size
MP Desai, V Labhasetwar, GL Amidon… - Pharmaceutical research, 1996 - Springer
Purpose. To investigate the effect of microparticle size on gastrointestinal tissue uptake.
Methods. Biodegradable microparticles of various sizes using polylactic polyglycolic acid (50:50) …
Methods. Biodegradable microparticles of various sizes using polylactic polyglycolic acid (50:50) …
Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards
R Löbenberg, GL Amidon - European journal of pharmaceutics and …, 2000 - Elsevier
In the last decade, the regulatory bioequivalence (BE) requirements of drug products have
undergone major changes. The introduction of the biopharmaceutics drug classification …
undergone major changes. The introduction of the biopharmaceutics drug classification …
A compartmental absorption and transit model for estimating oral drug absorption
XY Lawrence, GL Amidon - International journal of pharmaceutics, 1999 - Elsevier
This report describes a compartmental absorption and transit model to estimate the fraction
of dose absorbed and the rate of drug absorption for passively transported drugs in …
of dose absorbed and the rate of drug absorption for passively transported drugs in …
The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent
…, V Labhasetwar, E Walter, RJ Levy, GL Amidon - Pharmaceutical …, 1997 - Springer
Purpose. To study the uptake of biodegradable microparticles in Caco-2 cells. Methods.
Biodegradable microparticles of polylactic polyglycolic acid co-polymer (PLGA 50:50) of mean …
Biodegradable microparticles of polylactic polyglycolic acid co-polymer (PLGA 50:50) of mean …
Molecular properties of WHO essential drugs and provisional biopharmaceutical classification
…, KK Midha, VP Shah, GL Amidon - Molecular …, 2004 - ACS Publications
The purpose of this study is to provisionally classify, based on the Biopharmaceutics
Classification System (BCS), drugs in immediate-release dosage forms that appear on the World …
Classification System (BCS), drugs in immediate-release dosage forms that appear on the World …
[PDF][PDF] Biopharmaceutics classification system: the scientific basis for biowaiver extensions
Since the introduction of the Biopharmaceutics Classification System (BCS)(1), its validity and
applicability have been the subject of extensive research and discussion (2). These efforts …
applicability have been the subject of extensive research and discussion (2). These efforts …