Down-regulation of rat hepatic microsomal cytochromes P-450 in microvesicular steatosis induced by orotic acid

GM Su, RM Sefton, M Murray - Journal of Pharmacology and Experimental …, 1999 - ASPET
Microvesicular steatosis is an important component of the overall pathogenesis of drug-mediated
liver injury. Although mitochondrial damage has a role in the development of …

Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics

C Cowpland, GM Su, M Murray… - Clinical and …, 2006 - Wiley Online Library
Gloria M SuGloria M Su … The instrument was run in selected ion monitoring mode and
ions m/z 391 and m/z 393 (d 2 -internal standard), representing loss of pentafluorobenzyl radical …

The potential of N-[2-(dimethylamino) ethyl] acridine-4-carboxamide] to circumvent three multidrug-resistance phenotypes in vitro

RA Davey, GM Su, RM Hargrave, RM Harvie… - Cancer chemotherapy …, 1997 - Springer
The effectiveness of N-[2-(dimethylamino) ethyl]acridine-4-carboxamide (DACA) relative to
that of amsacrine, idarubicin, daunorubicin and paclitaxel against three different forms of …

Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid

GM Su, E Fiala-Beer, J Weber, D Jahn… - Biochemical …, 2005 - Elsevier
In rodents, high-fat diets promote hepatic lipid accumulation in rodents, activation of peroxisome
proliferator activated receptor-α (PPARα) and upregulation of cytochrome P450 (CYP) …

[HTML][HTML] Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver

M Murray, AM Butler, E Fiala-Beer, GM Su - FEBS letters, 2005 - Elsevier
The growth hormone (GH)-responsive cytochrome P450 (CYP) 2C11 is down-regulated in
vitamin A-deficient (VAD) rat liver. This study assessed the impact of a VAD diet on the …

Generic GPCR residue numbers–aligning topology maps while minding the gaps

…, JP Pin, RC Stevens, G Vriend, DE Gloriam - Trends in …, 2015 - cell.com
Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand
interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for …

[HTML][HTML] Bioactive amines in soy sauce: Validation of method, occurrence and potential health effects

LR Guidi, MBA Gloria - Food Chemistry, 2012 - Elsevier
The objective of this study was to investigate the levels of bioactive amines in soy sauce. A
method for the extraction of amines was optimized and an ion pair-HPLC method was …

Cadmium, copper and lead levels in different cultivars of lettuce and soil from urban agriculture

…, EAN Knupp, HEL Palmieri, JBB Silva, MBA Glória - Environmental …, 2018 - Elsevier
Urban agriculture plays an important role in sustainable food supply. However, because of
the atmospheric pollution and soil contamination associated with urban areas, this activity …

[PDF][PDF] 5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology

…, AA Jensen, MA Hanson, S Zhao, DE Gloriam… - Cell, 2018 - cell.com
Drugs frequently require interactions with multiple targets—via a process known as
polypharmacology—to achieve their therapeutic actions. Currently, drugs targeting several serotonin …

[PDF][PDF] Pharmacogenomics of GPCR drug targets

…, I Masuho, LJ Jahn, KA Martemyanov, DE Gloriam… - Cell, 2018 - cell.com
Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although 108 G-…