Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects
on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P X receptor agonist) …

Although obesity is a major risk factor for morbidity and mortality, the mechanisms mediating
cardiovascular abnormalities in response to weight gain are unclear. One reason for the …

Vascular calcification is a mortality risk factor for stage 5 chronic kidney disease patients. We
investigated the role of phosphorus and vitamin D analogs in the pathogenesis of vascular …

Levosimendan enhances cardiac contractility via Ca 2+ sensitization and induces vasodilation
through the activation of ATP-dependent K + and large-conductance Ca 2+ -dependent K …

Dipeptidyl peptidase IV (DPP4) deactivates glucose-regulating hormones such as GLP-1 and
GIP, thus, DPP4 inhibition has become a useful therapy for type 2 diabetes. Optimization of …

We previously reported that chronic hyperinsulinemia does not cause hypertension in normal
insulin-sensitive dogs. However, resistance to the metabolic and vasodilator effects of …

Background/Aims: Vitamin D receptor activators (VDRAs) may suppress renin expression and
VDR-mediated renin inhibitors may offer a novel mechanism to control the RAS. Methods: …

ABT‐089 [2‐methyl‐3‐(2‐(S)‐pyrrolidinylmethoxy)pyridine dihydrochloride salt] is a selective
neuronal nicotinic receptor (NNR) modulator with cognitive enhancing properties in animal …

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor
1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a …

Nonsteriodal anti-inflammatory drugs (NSAIDs) are efficacious for the treatment of pain
associated with inflammatory disease. Clinical experience with marketed selective …