Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory,
autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, …

Increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients has
been attributed to long-standing chronic inflammation, with the contribution of genetic …

Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel
disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and conversion to …

Colorectal cancer is the second most frequent cause of cancer death in the western world.
Although the prognosis has improved after the introduction of newer anticancer drugs, the …

A series of water-soluble fullerene C 60 derivatives has been investigated for their cytotoxic
and hemolytic properties, with the aim to correlate structure with toxicity. We observed that …

Importance Pediatric-onset Crohn disease is more aggressive than adult-onset disease,
has high rates of resistance to existing drugs, and can lead to permanent impairments. Few …

Background Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur
in 15%–38% of patients and the majority are not explained by thiopurine-S-…

Aims Ingestion of flavonoid-rich beverages acutely affects endothelial function, causing
vasodilation. This effect might be dependent on flavonoid transport into the endothelium. We …

Abstract Treatment-related toxicity can be life-threatening and is the primary cause of interruption
or discontinuation of chemotherapy for acute lymphoblastic leukemia (ALL), leading to …

Background Glucocorticoids (GCs) are used in moderate-to-severe inflammatory bowel
diseases (IBD) but their effect is often unpredictable. Aim To determine the influence of 4 …