Despite the progressive development of innovative animal models for Parkinson's disease,
the intracerebral infusion of neurotoxin 6‐hydroxydopamine (6‐OHDA) remains the most …

Stem cells have been increasingly recognized as a potential tool to replace or support cells
damaged by the neurodegenerative process that underlies Parkinson's disease (PD). In this …

Background Parkinson’s disease (PD) is frequently associated with gastrointestinal (GI)
symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying …

Heterozygous mutations in GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase
(GCase), are a major risk factor for sporadic Parkinson's disease (PD). Defective GCase …

Altered glutamatergic neurotransmission is central to the expression of Parkinson's disease (PD)
symptoms and may underlie l-DOPA-induced dyskinesias. Drugs acting on glutamate …

Gastrointestinal disorders, constipation in particular, are the most common non-motor
dysfunctions affecting Parkinson's disease (PD) patients. We have previously reported that rats …

Epidemiological data suggest a sexual dimorphism in Parkinson disease (PD), with women
showing lower risk of developing PD. Vulnerability of the nigrostriatal pathway may be …

This study demonstrates that mesenchymal stem cells infused through the carotid artery do
not efficiently cross the blood-brain barrier in rats with a Parkinson's disease-like …

Parkinson’s disease is frequently associated with gastrointestinal symptoms, mostly represented
by constipation and defecatory dysfunctions. This study examined the impact of central …

Complete Freund's adjuvant (CFA), a pro-inflammatory agent, was inoculated, subcutaneously,
to Sprague–Dawley rats prior to the intrastriatal injection of 6-hydroxydopamine (6-OHDA…