Preclinical Antitumor Activity of a New Vinca Alkaloid Derivative, S 12363
…, G Atassi, S Cros, MF Poupon, G Lavielle… - Cancer research, 1991 - AACR
S 12363 is a new Vinca alkaloid derivative obtained by appending an optically active α-aminophosphonate
at the C 23 position of O 4 -deacetyl vinblastine. S 12363 was evaluated for …
at the C 23 position of O 4 -deacetyl vinblastine. S 12363 was evaluated for …
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E–deficient mice: evidence that eicosanoids other than thromboxane …
…, Y Du, J Oliver-Krasinski, G Lavielle… - … , and vascular biology, 2000 - Am Heart Assoc
Atherosclerosis involves a complex array of factors, including leukocyte adhesion and
platelet vasoactive factors. Aspirin, which is used to prevent secondary complications of …
platelet vasoactive factors. Aspirin, which is used to prevent secondary complications of …
New. alpha.-amino phosphonic acid derivatives of vinblastine: chemistry and antitumor activity
G Lavielle, P Hautefaye, C Schaeffer… - Journal of medicinal …, 1991 - ACS Publications
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been
synthesizedand tested in vitro and in vivo for antitumor activity. The compounds were obtained from …
synthesizedand tested in vitro and in vivo for antitumor activity. The compounds were obtained from …
α-Aminophosphonates. III. Cycloaddition anionique-1,3 des esters α,β-insaturés: Préparation et transformations des Δ1-pyrrolines
…, JM Kanabus-Kaminska, G Lavielle - Canadian journal of …, 1988 - cdnsciencepub.com
Les anions des aza-2 allylphosphonates 1 se combinent avec les esters α,β-insaturés 2 en
donnant les intermédiaires chargés 4′. Ces intermédiaires conduisent à la suite de …
donnant les intermédiaires chargés 4′. Ces intermédiaires conduisent à la suite de …
S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models
…, JM Rivet, G Flik, TI Cremers, O Muller, G Lavielle… - …, 2008 - Springer
Rationale Serotonin (5-HT) 2C receptors are implicated in the control of mood, and their
blockade is of potential interest for the management of anxiodepressive states. Objectives …
blockade is of potential interest for the management of anxiodepressive states. Objectives …
S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: I. Receptorial, electrophysiological and neurochemical profile compared …
…, JM Rivet, V Audinot, T Dubuffet, G Lavielle - … of Pharmacology and …, 2000 - ASPET
The benzopyranopyrrole S33084 displayed pronounced affinity (pK i = 9.6) for cloned
human hD 3 -receptors, and >100-fold lower affinity for hD 2 and all other receptors (>30) …
human hD 3 -receptors, and >100-fold lower affinity for hD 2 and all other receptors (>30) …
S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: II. Functional and behavioral profile compared with GR218, 231 and L741 …
…, A Dekeyne, JM Rivet, T Dubuffet, G Lavielle… - … of Pharmacology and …, 2000 - ASPET
The selective dopamine D 3 -receptor antagonist S33084 dose dependently attenuated
induction of hypothermia by 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT) and PD128,907. …
induction of hypothermia by 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT) and PD128,907. …
S 16924 ((R)-2-{1-[2-(2, 3-dihydro-benzo [1, 4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl}-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked …
…, M Spedding, O Muller, G Lavielle… - … of Pharmacology and …, 1998 - ASPET
S 16924 antagonized locomotion provoked by dizocilpine and cocaine, reduced conditioned
avoidance responses and blocked climbing elicited by apomorphine, models predictive of …
avoidance responses and blocked climbing elicited by apomorphine, models predictive of …
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice
…, H Bayat, J Gu, JL Nadler, S Corda, G Lavielle… - Diabetes, 2006 - Am Diabetes Assoc
Arachidonic acid metabolites, some of which may activate thromboxane A 2 receptors (TPr)
and contribute to the development of diabetes complications, including nephropathy, are …
and contribute to the development of diabetes complications, including nephropathy, are …
Novel benzopyrano [3, 4-c] pyrrole derivatives as potent and selective dopamine D3 receptor antagonists
…, V Audinot, A Loutz, MJ Millan, G Lavielle - Bioorganic & medicinal …, 1999 - Elsevier
… Millan and Gilbert Lavielle*. … Dubuffet, T.; Loutz, A.; Lavielle, G.; Synthetic Comm. 1999,
29, 929-936. 13. … Cussac, D.; Newman-Tancredi, A.; Lejeune, F.; Gobert, A.; Audinot, V.; …
29, 929-936. 13. … Cussac, D.; Newman-Tancredi, A.; Lejeune, F.; Gobert, A.; Audinot, V.; …