Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
X Liu, N Shin, HK Koblish, G Yang… - Blood, The Journal …, 2010 - ashpublications.org
Indoleamine 2,3-dioxygenase-1 (IDO1; IDO) mediates oxidative cleavage of tryptophan, an
amino acid essential for cell proliferation and survival. IDO1 inhibition is proposed to have …
amino acid essential for cell proliferation and survival. IDO1 inhibition is proposed to have …
[PDF][PDF] Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
…, Y Lo, F Baribaud, I Mikami, N Reguart, G Yang… - Cancer cell, 2006 - cell.com
We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of
heregulin-dependent, HER2-mediated HER3 activation to gefitinib insensitivity in non-small …
heregulin-dependent, HER2-mediated HER3 activation to gefitinib insensitivity in non-small …
Hydroxyamidine inhibitors of indoleamine-2, 3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
HK Koblish, MJ Hansbury, KJ Bowman, G Yang… - Molecular cancer …, 2010 - AACR
Malignant tumors arise, in part, because the immune system does not adequately recognize
and destroy them. Expression of indoleamine-2,3-dioxygenase (IDO; IDO1), a rate-limiting …
and destroy them. Expression of indoleamine-2,3-dioxygenase (IDO; IDO1), a rate-limiting …
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
…, R Wynn, R Huber, M Hillman, G Yang… - Cancer biology & …, 2006 - Taylor & Francis
… Phillip CC Liu Xiangdong Liu Yanlong Li Maryanne Covington Richard Wynn Reid Huber
Milton Hillman Gengjie Yang Dawn Ellis Cindy Marando Kamna Katiyar Jodi Bradley Kenneth …
Milton Hillman Gengjie Yang Dawn Ellis Cindy Marando Kamna Katiyar Jodi Bradley Kenneth …
A novel kinase inhibitor, INCB28060, blocks c-MET–dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3
X Liu, Q Wang, G Yang, C Marando, HK Koblish… - Clinical cancer …, 2011 - AACR
Purpose: The c-MET receptor tyrosine kinase plays important roles in the formation, progression,
and dissemination of human cancer and presents an attractive therapeutic target. This …
and dissemination of human cancer and presents an attractive therapeutic target. This …
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α
…, YC Lo, Z Li, P Strzemienski, G Yang… - Proceedings of the …, 2001 - National Acad Sciences
The binding of tumor necrosis factor alpha (TNF-α) to the type-1 TNF receptor (TNFRc1)
plays an important role in inflammation. Despite the clinical success of biologics (antibodies, …
plays an important role in inflammation. Despite the clinical success of biologics (antibodies, …
Characterization of INCB086550: a potent and novel small-molecule PD-L1 inhibitor
…, K Kapilashrami, E Behshad, M Covington, Y Yang… - Cancer Discovery, 2022 - AACR
We have identified a potent small-molecule inhibitor of PD-L1, INCB086550, which has
biological properties similar to PD-L1/PD-1 monoclonal antibodies and may represent an …
biological properties similar to PD-L1/PD-1 monoclonal antibodies and may represent an …
Induction of aggrecanase 1 (ADAM‐TS4) by interleukin‐1 occurs through activation of constitutively produced protein
MA Pratta, PA Scherle, G Yang, RQ Liu… - Arthritis & …, 2003 - Wiley Online Library
Objective To study the production of aggrecanase 1 (ADAM‐TS4) in monolayer chondrocytes,
capsular fibroblasts, and cartilage. Methods Bovine nasal and articular cartilage, …
capsular fibroblasts, and cartilage. Methods Bovine nasal and articular cartilage, …
Both 5-arylidene-2-thioxodihydropyrimidine-4, 6 (1H, 5H)-diones and 3-thioxo-2, 3-dihydro-1H-imidazo [1, 5-a] indol-1-ones are light-dependent tumor necrosis factor …
…, LA Thompson, M Xu, YC Lo, G Yang… - Bioorganic & medicinal …, 2003 - Elsevier
Based on the realization that N-alkyl 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones are tumor
necrosis factor-α antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,…
necrosis factor-α antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,…
Hydroelectric generating unit fault diagnosis using 1-D convolutional neural network and gated recurrent unit in small hydro
GP Liao, W Gao, GJ Yang, MF Guo - IEEE Sensors Journal, 2019 - ieeexplore.ieee.org
Machine learning algorithm based on hand-crafted features from the raw vibration signal has
shown promising results in the hydroelectric generating unit (HGU) fault diagnosis in recent …
shown promising results in the hydroelectric generating unit (HGU) fault diagnosis in recent …