HMGB1 and RAGE in inflammation and cancer

GP Sims, DC Rowe, ST Rietdijk… - Annual review of …, 2009 - annualreviews.org
The immune system has evolved to respond not only to pathogens, but also to signals released
from dying cells. Cell death through necrosis induces inflammation, whereas apoptotic …

Modulatory effects of 1, 25-dihydroxyvitamin D3 on human B cell differentiation

S Chen, GP Sims, XX Chen, YY Gu, S Chen… - The Journal of …, 2007 - journals.aai.org
25-Dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) can modulate immune responses, but whether it
directly affects B cell function is unknown. Patients with systemic lupus erythematosus, …

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells

R Ettinger, GP Sims, AM Fairhurst… - The Journal of …, 2005 - journals.aai.org
IL-21 is a type I cytokine that influences the function of T cells, NK cells, and B cells. In this
study, we report that IL-21 plays a major role in stimulating the differentiation of human B cells. …

Identification and characterization of circulating human transitional B cells

GP Sims, R Ettinger, Y Shirota, CH Yarboro, GG Illei… - Blood, 2005 - ashpublications.org
Murine B-cell development begins in bone marrow and results in the generation of immature
transitional B cells that transit to the spleen to complete their maturation. It remains unclear …

Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

S Kuchen, R Robbins, GP Sims, C Sheng… - The journal of …, 2007 - journals.aai.org
During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are
known to require T cell-derived soluble factors. However, the exact nature of the cytokines …

Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease

…, M Maret, MC Dombret, GP Sims… - American journal of …, 2010 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airway
inflammation and remodeling. High-mobility group box 1 (HMGB1), a nuclear protein that is …

Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27

RD Fritsch, X Shen, GP Sims, KS Hathcock… - The Journal of …, 2005 - journals.aai.org
To study the steps in the differentiation of human memory CD4 T cells, we characterized the
functional and lineage relationships of three distinct memory CD4 subpopulations …

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

…, J Tian, CS Chang, PS Chowdhury, GP Sims… - Journal of Experimental …, 2013 - rupress.org
Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way
the mammalian immune system senses infection and tissue damage. Activation of immune …

Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis

GP Sims, H Shiono, N Willcox, DI Stott - The Journal of Immunology, 2001 - journals.aai.org
The muscle weakness in myasthenia gravis (MG) is mediated by autoantibodies against the
nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. Production of these …

IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells

R Ettinger, GP Sims, R Robbins, D Withers… - The Journal of …, 2007 - journals.aai.org
Both constitutive Ig secretion by long-lived plasma cells (PC) and the recurrent differentiation
of memory (mem) B cells into PC contribute to the maintenance of serologic mem. However…