Human β3-adrenergic receptor agonists containing 1, 2, 3-triazole-substituted benzenesulfonamides

…, L Deng, WP Feeney, MJ Forrest, GJ Hom… - Bioorganic & medicinal …, 2000 - Elsevier
Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared
and found to be potent and selective human β 3 -adrenergic receptor agonists. The most …

Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl) …

…, DE Cashen, JE Drisko, GJ Hom… - Journal of medicinal …, 2002 - ACS Publications
Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have
been found to be anorexigenic and to stimulate erectile activity. We report the design and …

Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula

…, DE Cashen, LT Gantert, JE Drisko, GJ Hom… - European journal of …, 2002 - Elsevier
Melanocortin peptide agonists, α-melanocyte stimulating hormone (α-MSH) and melanotan-II,
stimulate erectile activity in a variety of species, including man. Since neither peptide …

Physiological and pharmacological properties of vanadium

BS Jandhyala, GJ Hom - Life sciences, 1983 - Elsevier
Vanadium is distributed extensively in nature. It is a trace element and is present in almost
all living organisms including man. Even though vanadium was originally recognized for its …

Comparison of cardiovascular parameters and/or serum chemistry and hematology profiles in conscious and anesthetized rhesus monkeys (Macaca mulatta)

GJ Hom, TJ Bach, D Carroll, MJ Forrest… - Journal of the …, 1999 - ingentaconnect.com
The rhesus monkey is often used in pre-clinical research, and such studies frequently
involve a variety of anesthetic conditions. Therefore, it is important to determine baseline …

L-770,644: a potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

…, L Deng, WP Feeney, MJ Forrest, GJ Hom… - Bioorganic & medicinal …, 1999 - Elsevier
L-770,644 (9c) is a potent and selective agonist of the human β 3 adrenergic receptor (EC
50 = 13 nM). It shows good oral bioavailability in both dogs and rats (%F = 27), and is a full …

[PDF][PDF] Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the …

GJ Hom, SK Grant, G Wolfe, TJ Bach… - … of Pharmacology and …, 1995 - Citeseer
ABBREVIATIONS: NO, nitric oxide; NOS, nitric oxide synthase; EDRF, endothelium-denved
relaxing factor cNOS, constltutive NOS; INOS, inducible NOS; DEX, dexamethasone; LPS, …

Discovery of a Potent, Orally Bioavailable β3 Adrenergic Receptor Agonist, (R)-N-[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl) …

…, L Deng, WP Feeney, MJ Forrest, GJ Hom… - Journal of medicinal …, 2000 - ACS Publications
As part of our investigation into the development of orally bioavailable β 3 adrenergic receptor
agonists, we have identified a series of pyridylethanolamine analogues possessing a …

Human β3 andrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

…, L Deng, WP Feeney, MJ Forrest, GJ Hom… - Bioorganic & medicinal …, 1999 - Elsevier
The cyclopentylpropylimidazolidinone L-766,892 is a potent β 3 AR agonist (EC 50 5.7 nM,
64% activation) with 420- and 130-fold selectivity over binding to the β 1 and β 2 ARs, …

3-pyridylethanolamines: Potent and selective human β3 adrenergic receptor agonists

…, L Deng, WP Feeney, MJ Forrest, GJ Hom… - Bioorganic & Medicinal …, 1998 - Elsevier
The 3-pyridylethanolamine L-757,793 is a potent β 3 AR agonist (EC 50 6.3 nM, 70% activation)
with 1,300- and 500-fold selectivity over binding to the β 1 and β 2 ARs, respectively, L-…