Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase
…, H Kreipe, A Braun, G Shahaf… - Proceedings of the …, 2013 - National Acad Sciences
The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema
in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit …
in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit …
α-1 Antitrypsin promotes semimature, IL-10–producing and readily migrating tolerogenic dendritic cells
E Ozeri, M Mizrahi, G Shahaf… - The Journal of Immunology, 2012 - journals.aai.org
Tolerogenic IL-10–positive CCR7-positive dendritic cells (DC) promote T regulatory (Treg)
cell differentiation upon CCR7-dependent migration to draining lymph nodes (DLN). Indeed, …
cell differentiation upon CCR7-dependent migration to draining lymph nodes (DLN). Indeed, …
Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+ FoxP3+ Treg cell population and prevents signs of experimental …
S Subramanian, G Shahaf, E Ozeri, LM Miller… - Metabolic brain …, 2011 - Springer
Alpha-1-antitrypsin (AAT) is the primary circulating serine protease inhibitor, and is known to
exert potent anti-inflammatory effects and to inhibit the progression of several autoimmune …
exert potent anti-inflammatory effects and to inhibit the progression of several autoimmune …
Acute Phase Protein α1-Antitrypsin Reduces the Bacterial Burden in Mice by Selective Modulation of Innate Cell Responses
Z Kaner, DE Ochayon, G Shahaf… - The Journal of …, 2015 - academic.oup.com
Background. Severe bacterial infection can cause sepsis, multiple organ dysfunction
syndrome (MODS), and death. Human α 1 -antitrypsin (hAAT) is an antiinflammatory, immune-…
syndrome (MODS), and death. Human α 1 -antitrypsin (hAAT) is an antiinflammatory, immune-…
[HTML][HTML] α-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection
G Shahaf, H Moser, E Ozeri, M Mizrahi, A Abecassis… - Molecular …, 2011 - Springer
Antiinflammatory clinical-grade, plasma-derived human α-1 antitrypsin (hAAT) protects
islets from allorejection as well as from autoimmune destruction. hAAT also interferes with …
islets from allorejection as well as from autoimmune destruction. hAAT also interferes with …
[HTML][HTML] α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation
A Abecassis, R Schuster, G Shahaf, E Ozeri… - Cellular & molecular …, 2014 - nature.com
Although islet transplantation for individuals with type 1 diabetes has been shown to yield
superior blood glucose control, it remains inadequate for long-term control. This is partly due …
superior blood glucose control, it remains inadequate for long-term control. This is partly due …
PKCη enhances cell cycle progression, the expression of G1 cyclins and p21 in MCF-7 cells
E Fima, M Shtutman, P Libros, A Missel, G Shahaf… - Oncogene, 2001 - nature.com
Protein kinase C encodes a family of enzymes implicated in cellular differentiation, growth
control and tumor promotion. However, not much is known with respect to the molecular …
control and tumor promotion. However, not much is known with respect to the molecular …
PKCη is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation:: C1b domain and the …
A Maissel, M Marom, M Shtutman, G Shahaf, E Livneh - Cellular signalling, 2006 - Elsevier
Protein kinase C (PKC) represents a family of serin/threonine kinases, playing a central role
in the regulation of cell growth, differentiation and transformation. These enzymes differ in …
in the regulation of cell growth, differentiation and transformation. These enzymes differ in …
Low levels of circulating alpha-1 antitrypsin are associated with spontaneous abortions
T Madar, G Shahaf, E Sheiner, J Brazg… - The journal of …, 2013 - Taylor & Francis
Objective: Alpha-1 antitrypsin (AAT), a circulating anti-inflammatory molecule, rises four- to
sixfold during acute phase responses and during pregnancy. AAT deficiency is linked with …
sixfold during acute phase responses and during pregnancy. AAT deficiency is linked with …
Lower circulation levels and activity of α-1 antitrypsin in pregnant women with severe preeclampsia
G Twina, E Sheiner, G Shahaf… - The Journal of …, 2012 - Taylor & Francis
Objective: α-1 antitrypsin (AAT) is an anti-protease, anti-inflammatory and tissue-protective
molecule. Normal circulating levels are <3.5 mg/dl and rise during pregnancy. Although AAT …
molecule. Normal circulating levels are <3.5 mg/dl and rise during pregnancy. Although AAT …