The activation of T-cells and macrophages and subsequent induction of cytokines are critical
factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, eg TNF …

Concanavalin A (Con A) causes severe TNF-α–mediated and IFN-γ–mediated liver injury in
mice. In addition to their other functions, TNF-α and IFN-γ both induce the inducible nitric …

Heme oxygenase–1 (HO–1), a stress–responsive enzyme that catabolizes heme into
carbon monoxide (CO), biliverdin, and iron, has previously been shown to protect grafts from …

Background & Aims: Induction of heme oxygenase-1 (HO-1) has been shown to be beneficial
in immune-mediated liver damage. We now investigate the effects of HO-1 induction in …

Pseudomonas aeruginosa and Aspergillus fumigatus are common opportunistic bacterial
and fungal pathogens, respectively. They often coexist in airways of immunocompromised …

The anti‐inflammatory and antiapoptotic heme degrading enzyme heme oxygenase‐1 (HO‐1)
has been shown recently to interfere with replication of hepatitis C virus (HCV). We …

The Nef protein of human and primate lentiviruses is a key factor in HIV/SIV pathogenesis.
Here we report that Nef associates with two different kinases, forming a multiprotein complex …

Increasing evidence indicates that inflammation of visceral organs is significantly affected
by the autonomic nervous system. Such neuroimmune interactions have not been studied in …

Endogenous overexpression of the antiapoptotic protein heme oxygenase 1 (HO‐1) has
been shown to occur in various cancer diseases and might contribute to cancer progression. …

TNF-α has been clearly identified as central mediator of T cell activation-induced acute hepatic
injury in mice, eg, Con A hepatitis. In this model, liver injury depends on both TNFRs, ie, …