Reduction of J-inethyl-d-ary 1-4 (311)-quinazolinone hydrochloride (VIII, Ar=(Jells, 2-Cll» C
«Ht, and2, 3-(CIIj) jC «lí») with XaBIL gave the corresponding 2-methyl-3-aryl-4-oNo-|, 2, 3, 4-…

The equivalent of pA 2 values were determined for morphine-naloxone in mice using the tail-flick,
hot plate and writhing analgesic assays. In spite of marked differences in the ED 50 of …

The equivalents of pA 2 values were determined for morphine, pentazocine and etorphine
using the antagonists, naloxone and diprenorphine, and the writhing analgesic assay. The …

There is a gradual increase in the brain 5-hydroxytryptamine (5-HT) turnover rate over a
three-day period after morphine pellet implantation in mice. p-Chlorophenylalanine (PCPA) …

2-Methyl analogs of certain3-alkyl-3-phenylpiperidine derivatives havebeen synthesized and
tested for anal-gesic activity. 1-Phenacyl derivative of the 2, 3-dimethyl compound (11) was …

Methods.—(1) Analgesic Activity and Toxicity.—Analgesic effect was measured by the hot-plate
method. 3 ED50 values were calculated4 from the pain reaction time of each group of 10 …

I11 a effort to prepare nonequilibrium analgetic receptor inactivators, a variety of N-acylanileridines
having alkylating capacity were synthesized. The analgetic potencies of this series …

Reaction of 2-(N-ethylacet, amido) beiizanilidc with HI in ElOII afforded l-ethyl-2-methyI-3-phenyl-4-o\ndihydmquinazolinium
iodide in quantitative yield. This conversion was reversible …

The synthesis of the compounds was accomplished according to the route shown in Chart 2.
The compounds prepared are listed in Tables I, II, and III. Reduction of 2-nitrothiophene …

A series of octahydrobenzo [/] quinolines (Ilia) and hexahydro-l/f-benz [e] indoles (Illb), rigid
structures related to 3-phenylpiperidine and pyrrolidine analgetics, has been synthesized. …