5-Hydroxyindole potentiates human α7 nicotinic receptor-mediated responses and enhances acetylcholine-induced glutamate release in cerebellar slices

R Zwart, G De Filippi, LM Broad, GI McPhie… - …, 2002 - Elsevier
The effects of 5-hydroxyindole (5-HI) have been investigated on human α7 nicotinic
acetylcholine receptors (nAChRs) expressed in Xenopus oocytes and GH4 cells, on native α7 …

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators

…, KH Pearson, M Lee, L Wallace, GI McPhie… - … of Pharmacology and …, 2006 - ASPET
Here we report the discovery, by high-throughput screening, of three novel (2-amino-5-keto)thiazole
compounds that act as selective potentiators of nicotinic acetylcholine receptors. …

PSAB-OFP, a selective α7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor

LM Broad, C Felthouse, R Zwart, GI McPhie… - European journal of …, 2002 - Elsevier
5-Hydroxytryptamine 3 (5-HT 3 ) and α7 nicotinic receptors share high sequence homology
and pharmacological cross-reactivity. An assessment of the potential role of α7 receptors in …

Stable expression and characterisation of a human α7 nicotinic subunit chimera: a tool for functional high-throughput screening

…, G Benedetti, KH Pearson, GI McPhie… - European journal of …, 2004 - Elsevier
A chimera comprising the N-terminal region of the human α7 nicotinic acetylcholine receptor,
fused to the transmembrane/C-terminal domains of the mouse serotonin 5-HT 3 receptor, …

Expression and functional characterisation of a human chimeric nicotinic receptor with α6β4 properties

…, G Benedetti, R Zwart, KH Pearson, GI McPhie… - European journal of …, 2003 - Elsevier
Despite being cloned several years ago, the expression of functional nicotinic acetylcholine
receptors containing the human α6 subunit in recombinant mammalian cell lines has yet to …

An integrated cardiovascular and neurobehavioural functional assessment in the conscious telemetered cynomolgus monkey

E Moscardo, G McPhie, N Fasdelli, R Dorigatti… - … of Pharmacological and …, 2010 - Elsevier
INTRODUCTION: Unwanted effects of drugs on neurobehavioural and cardiovascular functions
are normally assessed in separate studies and using different animals. The purpose of …

Viscosity of a binary mixture: Approach to the hydrodynamic limit

MG McPhie, PJ Daivis, IK Snook - Physical Review E, 2006 - APS
We have used equilibrium and nonequilibrium molecular dynamics simulations to study the
solute self-diffusion coefficient and the shear rate dependence of the solution viscosity in …

Generalized Langevin equation for nonequilibrium systems

MG McPhie, PJ Daivis, IK Snook, J Ennis… - Physica A: Statistical …, 2001 - Elsevier
We derive a generalized Langevin Equation (GLE) for the evolution of an arbitrary phase
variable in a classical fluid that is initially at equilibrium and is subsequently subjected to an …

A rate theory study of helium bubble formation and retention in Cu–Nb nanocomposites

AY Dunn, MG McPhie, L Capolungo, E Martinez… - Journal of nuclear …, 2013 - Elsevier
A spatially dependent rate theory model for helium migration, clustering, and trapping on
interfaces between Cu and Nb layers is introduced to predict the evolution of the concentrations …

Activation energy for nucleation of partial dislocation from grain boundaries

MG McPhie, S Berbenni, M Cherkaoui - Computational materials science, 2012 - Elsevier
The nudged elastic band method has been used to calculate the activation energies for the
nucleation of the leading partial dislocation from grain boundaries in pure fcc copper under …