[HTML][HTML] Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
Specific tyrosine kinase inhibitors (TKIs) are rapidly developing clinical tools applied for the
inhibition of malignant cell growth and metastasis formation. Most of these newly developed …
inhibition of malignant cell growth and metastasis formation. Most of these newly developed …
[HTML][HTML] Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
Protein kinases are pivotal regulators of cell signaling that modulate each other's functions
and activities through site-specific phosphorylation events. These key regulatory …
and activities through site-specific phosphorylation events. These key regulatory …
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter
…, G Várady, O Ujhelly, JD Schuetz, A Varadi, G Kéri… - Molecular …, 2004 - ASPET
Tyrosine kinase inhibitors (TKIs) are promising new agents for specific inhibition of
malignant cell growth and metastasis formation. Because most of the TKIs have to reach an …
malignant cell growth and metastasis formation. Because most of the TKIs have to reach an …
Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties
…, M Magocsi, K Nemet, L Őrfi, G Kéri… - British journal of …, 2009 - Wiley Online Library
Background and purpose: ABC multidrug transporters (MDR‐ABC proteins) cause multiple
drug resistance in cancer and may be involved in the decreased anti‐cancer efficiency and …
drug resistance in cancer and may be involved in the decreased anti‐cancer efficiency and …
[HTML][HTML] Large-scale proteomics analysis of the human kinome
Members of the human protein kinase superfamily are the major regulatory enzymes involved
in the activity control of eukaryotic signal transduction pathways. As protein kinases reside …
in the activity control of eukaryotic signal transduction pathways. As protein kinases reside …
AXL is a potential target for therapeutic intervention in breast cancer progression
…, YP Knyazev, L Orfi, I Szabadkai, H Daub, G Kéri… - Cancer research, 2008 - AACR
Protein kinases play important roles in tumor development and progression. A variety of
members of this family of signal transduction enzymes serve as targets for therapeutic …
members of this family of signal transduction enzymes serve as targets for therapeutic …
Cellular targets of gefitinib
…, M Weber, S Müller, B Klebl, M Cotten, G Kéri… - Cancer research, 2005 - AACR
… g (1.00 mmol) 4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-ol was refluxed
in 20 mL acetonitrile with 0.26 g (1.10 mmol) N-BOC-3-propyl-bromide and 0.15 g (… , 0.25 g (…
in 20 mL acetonitrile with 0.26 g (1.10 mmol) N-BOC-3-propyl-bromide and 0.15 g (… , 0.25 g (…
Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib)
Iressa (ZD1839, Gefitinib), used in clinics to treat non–small cell lung cancer patients, is a
tyrosine kinase receptor inhibitor that leads to specific decoupling of epidermal growth factor …
tyrosine kinase receptor inhibitor that leads to specific decoupling of epidermal growth factor …
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
A Steták, R Veress, J Ovádi, P Csermely, G Keri… - Cancer research, 2007 - AACR
… We have shown previously that TT-232 acts trough seven-pass transmembrane somatostatin
receptors to induce G 1 cell cycle arrest (5). This antiproliferative effect is mediated by the …
receptors to induce G 1 cell cycle arrest (5). This antiproliferative effect is mediated by the …
Antiinflammatory and analgesic effects of somatostatin released from capsaicin‐sensitive sensory nerve terminals in a Freund's adjuvant–induced chronic arthritis …
…, E Pintér, A Bánvölgyi, L Kereskai, G Kéri… - Arthritis & …, 2004 - Wiley Online Library
Objective We previously demonstrated that somatostatin (SOM) released from the activated
peripheral terminals of capsaicin‐sensitive primary sensory neurons inhibits acute …
peripheral terminals of capsaicin‐sensitive primary sensory neurons inhibits acute …