A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation

S Vemula, KE Roder, T Yang, GJ Bhat… - … of Pharmacology and …, 2009 - ASPET
In the current study, we determined the functional significance of sodium-dependent/-independent
glucose transporters at the neurovasculature during oxygen glucose deprivation (OGD…

An extensively edited mitochondrial transcript in kinetoplastids encodes a protein homologous to ATPase subunit 6

GJ Bhat, DJ Koslowsky, JE Feagin, BL Smiley, K Stuart - Cell, 1990 - cell.com
Results The T. brucei MURF4 Transcript Is Extensively Edited The sequence of edited RNA
cannot as yet be predicted from the DNA sequence. However, since editing occurs in the 3’to …

The MURF3 gene of T. brucei contains multiple domains of extensive editing and is homologous to a subunit of NADH dehydrogenase

DJ Koslowsky, GJ Bhat, AL Perrollaz, JE Feagin… - Cell, 1990 - cell.com
Mitochondriai MURF3 transcripts of T. brucei are extensively edited by the addition and
deletion of uridines. The editing creates potential initiation and termination codona and a …

Cyclin A2 and CDK2 as novel targets of aspirin and salicylic acid: a potential role in cancer prevention

…, G Ai, DR Kumar, SS Sadhu, H Tummala, GJ Bhat - Molecular Cancer …, 2016 - AACR
Data emerging from the past 10 years have consolidated the rationale for investigating the
use of aspirin as a chemopreventive agent; however, the mechanisms leading to its …

[HTML][HTML] Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer

…, T Seefeldt, H Tummala, GJ Bhat - International …, 2017 - spandidos-publications.com
Aspirin's potential as a drug continues to be evaluated for the prevention of colorectal cancer
(CRC). Although multiple targets for aspirin and its metabolite, salicylic acid, have been …

Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin

…, SS Kesharwani, H Mathur, M Tyagi, GJ Bhat… - European Journal of …, 2016 - Elsevier
Curcumin is a natural dietary compound with demonstrated potential in preventing/treating
several chronic diseases in animal models. However, this success is yet to be translated to …

Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): formulation development, characterization and pharmacological evaluation

…, R Dachineni, CK Valiveti, S Kapur, GJ Bhat… - Journal of controlled …, 2018 - Elsevier
Inflammatory Bowel Diseases (IBD) is a debilitating condition that affects ~70,000 new
people every year and has been described as “an expensive disease with no known cure”. In …

[HTML][HTML] The flavonoid metabolite 2, 4, 6-trihydroxybenzoic acid is a CDK inhibitor and an anti-proliferative agent: A potential role in cancer prevention

…, T Seefeldt, J Scaria, H Tummala, GJ Bhat - Cancers, 2019 - mdpi.com
G. Jayarama Bhat … Dachineni, R.; Kumar, DR; Callegari, E.; Kesharwani, SS;
Sankaranarayanan, R.; Seefeldt, T.; Tummala, H.; Bhat, GJ Salicylic acid metabolites and …

Does aspirin acetylate multiple cellular proteins?

…, KS Srivenugopal, GJ Bhat - Molecular medicine …, 2009 - spandidos-publications.com
Aspirin is a salicylate drug that is extensively used for its anti-inflammatory, antipyretic, analgesic
and anti-thrombotic effects. More recently, it has been shown to decrease the incidence …

Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines

SK Niture, CS Velu, QR Smith, GJ Bhat… - …, 2007 - academic.oup.com
O 6 -Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which protects
the cellular genome and critical oncogenic genes from the mutagenic action of endogenous …