… binds to a single heterotrimeric G protein (G q/11 for P2Y 1,2,4,6 ), although P2Y 11 can
couple to both G q/11 , and G s , whereas P2Y 12 and P2Y 13 couple to G i and P2Y 14 to G i/o . …

… The studies reported in this review have, in the main, been carried out since 1978 when
Burnstock proposed a subdivision of purinoceptors into PI- and P2-purinoceptors. Novel P2-…

… cotransmission was in a paper published by Burnstock and Hohnan in 1962, in which they …
the time that adrenoceptor antagonists were ineffective (Burnstock and Holman, 1962). It was …

… to G proteins. Based on differences in molecular structure and signal transduction mechanisms,
P2 receptors divide naturally into two families of ligandgated ion channels and G protein-…

… introduced by Burnstock in 1972 [2]. … G protein-coupled P2 receptors were cloned [8, 9],
and a year later two ion-gated receptors were cloned [10, 11]. In 1994 Abbracchio and Burnstock …

… To test the effects of stimulation of extrinsic sympathetic or intramural nerves, preparations of
guinea-pig taenia coli and rabbit ileum were set up as described by Burnstock et al. (1966) and …

Extracellular ATP is implicated in numerous sensory processes ranging from the response to
pain to the regulation of motility in visceral organs 1 . The ATP receptor P2X 3 is selectively …

… In 1978 Burnstock made the important suggestion that there … , P 1 and P 2 (Burnstock, 1978).
A somewhat extended version … Thus, they probably interact with the G-protein, G s . It is not …

… , where two main receptor families have been recognised, one mediating fast receptor
responses directly linked to an ion channel, the other mediating slower responses through G-…

This review is aimed at providing readers with a comprehensive reference article about the
distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each …