User profiles for G. K. Acquaah-Mensah

George K Acquaah Mensah

Professor of Pharmaceutical Sciences, Massachusetts College of Pharmacy & Health …
Verified email at mcphs.edu
Cited by 2045

A tale of two diseases: Exploring mechanisms linking diabetes mellitus with Alzheimer's disease

…, C Ogunwale, GK Acquaah-Mensah - Journal of …, 2022 - content.iospress.com
Dementias, including the type associated with Alzheimer’s disease (AD), are on the rise
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …

The compositional structure of Gene Ontology terms

PV Ogren, KB Cohen, GK Acquaah-Mensah… - Biocomputing …, 2003 - World Scientific
An analysis of the term names in the Gene Ontology reveals the prevalence of substring
relations between terms: 65.3% of all GO terms contain another GO term as a proper substring. …

Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice

…, MA Elfawal, MJ Towler, GK Acquaah-Mensah… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance The Chinese have used Artemisia annua as a tea infusion
to treat fever for >2000 years. The active component is artemisinin. Previously we showed …

[HTML][HTML] SAGA: a hybrid search algorithm for Bayesian Network structure learning of transcriptional regulatory networks

ES Adabor, GK Acquaah-Mensah, FT Oduro - Journal of biomedical …, 2015 - Elsevier
Bayesian Networks have been used for the inference of transcriptional regulatory relationships
among genes, and are valuable for obtaining biological insights. However, finding …

A regulatory role for the insulin-and BDNF-linked RORA in the hippocampus: implications for Alzheimer's disease

GK Acquaah-Mensah, N Agu, T Khan… - Journal of Alzheimer's …, 2015 - content.iospress.com
Alzheimer's disease (AD) is the leading cause of dementia. The etiology of AD remains, in
large part, unresolved. In this study, gene expression (microarray) data from postmortem …

Restricted-derestricted dynamic Bayesian network inference of transcriptional regulatory relationships among genes in cancer

ES Adabor, GK Acquaah-Mensah - Computational biology and chemistry, 2019 - Elsevier
Understanding transcriptional regulatory relationships among genes is important for gaining
etiological insights into diseases such as cancer. To this end, high-throughput biological …

Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells

SS Biswal, K Datta, GK Acquaah-Mensah, JP Kehrer - Toxicology, 2000 - Elsevier
Fludarabine is used to treat chronic lymphocytic leukemia. Both in vitro and in vivo studies
have indicated that apoptosis is an important mode of fludarabine-induced cell death. …

[HTML][HTML] Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease

GK Acquaah-Mensah, D Malhotra… - PLoS computational …, 2012 - journals.plos.org
Chronic obstructive pulmonary disease (COPD) is a major global health problem. The
etiology of COPD has been associated with apoptosis, oxidative stress, and inflammation. …

Multi-omics inference of differential breast cancer-related transcriptional regulatory network gene hubs between young Black and White patients

B Aguilar, K Abdilleh, GK Acquaah-Mensah - Cancer Genetics, 2023 - Elsevier
Objective Breast cancers (BrCA) are a leading cause of illness and mortality worldwide. Black
women have a higher incidence rate relative to white women prior to age 40 years, and a …

Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights

GK Acquaah-Mensah, RC Taylor - Gene, 2016 - Elsevier
Microarray data have been a valuable resource for identifying transcriptional regulatory
relationships among genes. As an example, brain region-specific transcriptional regulatory …