… distinct from that of 5-HT 2A agonists since local application of phencyclidine to brain
slices does not result in an increase in EPSCs in layer V pyramidal cells of prefrontal cortex (Marek …

This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic
drugs from the early 1950s to the present day. There is now converging evidence from …

… induced by concurrent activation of 5-HT 2A receptors and electrical stimulation of the white
matter in a delayed manner with only partial efficacy followed by complete recovery (G Marek…

By intracellular and whole cell recording in rat brain slices, it was found that bath-applied
serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous …

… EPSPs in pyramidal neurons of the neocortex (Marek and Aghajanian, 1996), and this effect
is mimicked by application of DOI (GJ Marek and GK Aghajanian, personal communication). …

Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous
excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells …

In prefrontal cortex, 5-hydroxytryptamine 2A (5-HT 2A ) receptors have been linked to the
action of hallucinogens and atypical antidepressant/antipsychotic drugs. Previously, we have …

We compared 5-hydroxytryptamine (5-HT), norepinephrine and dopamine for their efficacy
at increasing excitatory postsynaptic current frequency in layer V pyramidal cells from rat …

Correlations between 5-hydroxytryptamine (5-HT) receptor binding affinities and human
hallucinogenic potency have suggested that 5-HT2 receptors mediate the hallucinogenic effects …

Dopamine D2 receptor blockade has been an obligate mechanism of action present in all
medications that effectively treat positive symptoms of schizophrenia (eg, delusions and …