Alteration in [Ca 2+ ] i (the intracellular concentration of Ca 2+ ) is a key regulator of many
cellular processes. To allow precise regulation of [Ca 2+ ] i and a diversity of signalling by this …

Drug repositioning or repurposing has received much coverage in the scientific literature in
recent years and has been responsible for the generation of both new intellectual property …

Nucleotides such as ATP and ADP act as intercellular messengers and exert a widespread
influence on cellular function by acting on a variety of cell surface receptors. Until recently, …

The C-terminal regions of glucagon-like peptide-1 (GLP-1) bind to the N terminus of the GLP-1
receptor (GLP-1R), facilitating interaction of the ligand N terminus with the receptor …

Background and purpose: The glucagon‐like peptide‐1 receptor (GLP‐1R) belongs to
Family B of the G protein‐coupled receptor superfamily and is a target for treatment of type 2 …

… Membranes were then collected on Whatman GF/B glass fiber filters presoaked in 0.5% (v/v)
polyethylenimine using a vacuum manifold (Millipore, Billerica, MA) washed through with 2…

We have examined the phospholipase C responses in bovine aortic endothelial cells to
purines (ATP, ADP and analogues) and the pyrimidine, uridine triphosphate (UTP). 2. The cells …

The chemical shifts of protons bonded directly to transition metals in groups such as Mn (CO)
a-and xC, H, Fe (CO),-, etc.(Table l), when compared with the shifts of hydrogen atoms …

We have functionally characterized the human recombinant somatostatin (SRIF) sst 5
receptor in Chinese hamster ovary‐K1 (CHOsst 5 ) cells by measuring total [ 3 H]‐inositol …

Interactions between pro-opiomelanocortin (POMC)-derived peptides, agouti-related protein
(AGRP) and the melanocortin-4 receptor (MC4-R) are central to energy homeostasis. In this …