Organic hydroperoxides such as tert-butyl hydroperoxide (TBHP) are cytotoxic to suspensions
of isolated hepatocytes. The exact mechanism of toxicity is unknown but may involve …

Chloroform (CHCI,, trichloromethane) is a heavy, colorless, volatile liquid at room temperature
and pressure. CHCI, is highly lipophilic (olive oil/air= 401) and was a majoi anesthetic in …

… In preclinical toxicity studies with Beagle dogs, Au(DPPE): produced toxicity in the liver,
the heart, and in the pulmonary vasculature (Rush et al., 1987). A comparison of isolated dog …

Au(DPPE)+2 (bis[1,2-bis(diphenylphosphino)ethane] gold(I] is an organo-gold antineoplastic
agent that has anti-tumor activity in a variety of in vitro cell lines and in vivo rodent tumor …

Acetaminophen (APAP) produced renal necrosis restricted to the straight segment of the
proximal tubule in Fischer 344 (F344) rats but not in Sprague-Dawley (SD) rats. APAP-induced …

Large doses of the cephalosporin antibiotic, cephaloridine, produce acute proximal tubular
necrosis in humans and in laboratory animals. Cephaloridine is actively transported into the …

SK&F 1 04524(bis-[1, 2 bis (diphenylphosphino)-ethane] gold (l) lactate)([Au (dppe) 2J) is
an experimental antineoplastic agent that is hepatotoxic in vivo in the dog as well as highly …

Isolated hepatocyes were prepared from fed and fasted rats and exposed to a range of
menadione (2-methyl-1,4-naphthoquinone) concentrations. Menadione (300 μm) caused a rapid …

Mitochondrial injury in aerobic mammalian cells is associated with a rapid depletion of adenosine
triphosphate (ATP) which occurs prior to the onset of lethal cell injury. In this report, the …

… (Rush GF, unpublished observations). In any event, decreases in GC3/cl cell ATP were not
observed in oivo and thus did not correlate with Sulofenur-induced reduction in tumor size. …