User profiles for G. B. Fox

Gerard Fox

VP, Abbott, AbbVie
Verified email at abbvie.com
Cited by 7101

[HTML][HTML] Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders

TA Esbenshade, GB Fox, MD Cowart - Molecular interventions, 2006 - triggered.clockss.org
… Komater, VA, Browman, KE, Curzon, P., Hancock, AA, Decker, MW, and Fox, GB H 3 receptor
blockade by thioperamide enhances cognition without inducing locomotor sensitization. …

[HTML][HTML] The behavioral assessment of sensorimotor processes in the mouse: acoustic startle, sensory gating, locomotor activity, rotarod, and beam walking

P Curzon, M Zhang, RJ Radek, GB Fox - 2011 - europepmc.org
Assessment of sensorimotor competence is an important part of the evaluation of animal
behavior. Measurement of sensorimotor performance is of obvious importance in investigations …

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury

AG Yakovlev, SM Knoblach, L Fan, GB Fox… - Journal of …, 1997 - Soc Neuroscience
We examined the temporal profile of apoptosis after fluid percussion-induced traumatic
brain injury (TBI) in rats and investigated the potential pathophysiological role of caspase-3-like …

Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse

GB FOX, LEI Fan, RA LEVASSEUR… - Journal of …, 1998 - liebertpub.com
A mouse model of traumatic brain injury was developed using a device that produces
controlled cortical impact (CCI), permitting independent manipulation of tissue deformation and …

PET imaging for receptor occupancy: meditations on calculation and simplification

Y Zhang, GB Fox - Journal of biomedical research, 2012 - Elsevier
This invited mini-review briefly summarizes procedures and challenges of measuring receptor
occupancy with positron emission tomography. Instead of describing the detailed analytic …

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl] ethyl}-benzofuran-5-yl) benzonitrile]: II. Neurophysiological characterization and broad …

GB Fox, TA Esbenshade, JB Pan, RJ Radek… - … of Pharmacology and …, 2005 - ASPET
Acute pharmacological blockade of central histamine H 3 receptors (H 3 Rs) enhances
arousal/attention in rodents. However, there is little information available for other behavioral …

Effect of traumatic brain injury on mouse spatial and nonspatial learning in the Barnes circular maze

GB FOX, L Fan, RA LeVASSEUR… - Journal of …, 1998 - liebertpub.com
Controlled cortical impact (CCI) is a relatively new model of traumatic brain injury in the
mouse, which, in combination with behavioral and histological methods, has potential for …

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

GB Fox, JB Pan, TA Esbenshade, YL Bennani… - Behavioural brain …, 2002 - Elsevier
Histamine H 3 receptor antagonists have been proposed as potentially useful therapeutic
agents for the treatment of several disorders including attention deficit, schizophrenia, …

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition …

…, JP Sullivan, TA Esbenshade, GB Fox… - Journal of medicinal …, 2005 - ACS Publications
… this model at 1−3 mg/kg, as described by Fox, 40 and by Yates 35 in a related 10-trial version…
Fox has reported the activity of thioperamide (2), ciproxifan (3), and 5 in the 5-trial inhibitory …

[HTML][HTML] Default-mode-like network activation in awake rodents

…, Y Lee, GJ Marek, U Sakoglu, CL Chin, F Luo, GB Fox… - PloS one, 2011 - journals.plos.org
Fox, and Mark Day are stated as employees of Abbott Laboratories during the time at which
Fox, and Mark Day are stated as employees of Abbott Laboratories during the time at which …