[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
…, B Kevin Park, C Kordes, GA Kullak-Ublick… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
Enterohepatic bile salt transporters in normal physiology and liver disease
GA Kullak-Ublick, B Stieger, PJ Meier - Gastroenterology, 2004 - Elsevier
The vectorial transport of bile salts from blood into bile is essential for the generation of bile
flow, solubilization of cholesterol in bile, and emulsification of lipids in the intestine. Major …
flow, solubilization of cholesterol in bile, and emulsification of lipids in the intestine. Major …
Current concepts of mechanisms in drug-induced hepatotoxicity
S Russmann, GA Kullak-Ublick… - Current medicinal …, 2009 - ingentaconnect.com
… Kullak-Ublick is supported by a grant from the Swiss National Science Foundation (32… [105]
Eloranta, JJ; Kullak-Ublick, GA Coordinate transcriptional regulation of bile acid homeostasis …
Eloranta, JJ; Kullak-Ublick, GA Coordinate transcriptional regulation of bile acid homeostasis …
Dual-functional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection
The ongoing outbreak of the novel coronavirus disease (COVID-19) has spread globally and
poses a threat to public health in more than 200 countries. Reliable laboratory diagnosis of …
poses a threat to public health in more than 200 countries. Reliable laboratory diagnosis of …
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
GA Kullak-Ublick, MG Ismair, B Stieger, L Landmann… - Gastroenterology, 2001 - Elsevier
Background & Aims: Hepatic uptake of cholephilic organic compounds is mediated by members
of the organic anion-transporting polypeptide (OATP) family. We aimed to characterize …
of the organic anion-transporting polypeptide (OATP) family. We aimed to characterize …
St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4
D Dürr, B Stieger, GA Kullak‐Ublick… - Clinical …, 2000 - Wiley Online Library
Background St John's Wort (hypericum perforatum) is an herbal medicine that is frequently
used for therapy of mild depression. Recently, St John's Wort was reported to substantially …
used for therapy of mild depression. Recently, St John's Wort was reported to substantially …
Drug-and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
B Stieger, K Fattinger, J Madon, GA Kullak-Ublick… - Gastroenterology, 2000 - Elsevier
Background & Aims: Drug-induced cholestasis is a frequent form of acquired liver disease.
To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the …
To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the …
EASL clinical practice guidelines: drug-induced liver injury
…, ES Björnsson, N Kaplowitz, GA Kullak-Ublick… - Journal of …, 2019 - Elsevier
Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, …
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, …
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
GA Kullak-Ublick, B Hagenbuch, B Stieger… - Gastroenterology, 1995 - Elsevier
… Kullak-Ublick was a recipient of a postdoctoral research fellowship award from the Deutsche
Forschungsgemeinschaft (Bonn, Germany). Presented in part at the biannual meeting of …
Forschungsgemeinschaft (Bonn, Germany). Presented in part at the biannual meeting of …
Drug-induced liver injury
…, ES Björnsson, A Suzuki, GA Kullak-Ublick… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …
occurs either as a predictable event when an individual is exposed to toxic doses of some …