Application of enzyme regulation to chemotherapy of human cancer can be a highly fruitful
endeavor, not only in terms of possible benefits to patients, but also in terms of the genesis of …

Screening for soil cultures producing agents displaying both cytotoxic activity against L1210
cells in culture and in vivo activity against P388 leukemia in mice afforded a culture, …

ACIVICIN [([alpha] S, 5S)-[alpha]-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid; AT-125;
NSC-163501] is a fermentation product of Streptomyces sviceus which is active in a …

The antitumor activities of 2, 3-dihydro-2-(1-naphthyl)-4 (1H)-quinazolinone (NSC-145669),
an antispermatogenic agent, and a number of related quinazolinone derivatives have been …

The drugs [1-β-d-arabinofuranosylcytosine (ara-C), hydroxyurea (HU), 5-hydroxy-2-formylpyridine
thiosemicarbazone (5-HP), and camptothecin sodium salt (camptothecin)] considered …

Cytarabine (ara-C) (1-β-d-arabinofuranosylcytosine, Cytosar) is useful in the treatment of
human leukemias. In experimental animals, po doses required to elicit an antitumor effect are …

(αS, 5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) isolated from
fermentation broths of Streptomyces sviceus was found to have significant activity against a …

For over 20 years, The Upjohn Company has conducted research directed towards the
detection, isolation, purification, characterization, and development of fermentation-derived …

… Neil, PhD, Experimental Biology Research Department, Cancer Research, The Upjohn …
HAŇKA LJ, KUENTZEL SL, and NEIL GL. Improved microbiological assay for cytosine …

… LJ Hanka, DG Martin, GL Neil …