… Carlsson L, Abrahamsson C, Drews L, Duker G. Antiarrhythmic effects of potassium channel
openers in rhythm abnormalities related to delayed repolarization. Circulation 1992;85: 1491…

Background—Prolongation of action potential duration (APD) is considered a major
antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade …

The aims of this report are firstly to raise awareness among kineticists and pharmacologists
as to why pharmacokinetic–pharmacodynamic (PKPD) integration is essential for target …

BACKGROUND: Gender differences in cardiac electrophysiology were reported for the first
time almost a century ago. The importance for safety pharmacology became significant when …

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a
new model for safety pharmacology. So far, a thorough description of their basic …

… (C–G) Primary NPC1 mutant and healthy control MDM were infected with GFP-S. … (G)
Absolute numbers of bacteria per MDM for indicated groups. (H) Infection experiment performed as …

When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia
(VT) with features typical of torsades de pointes developed. This arrhythmia was further …

Picornavirus RNAs are uncapped messengers and have unusually long 5' nontranslated
regions (5'NTRs) which contain many noninitiating AUG triplets. The translational efficiency of …

Nucleotide sequence comparisons were performed on a highly heterogeneous region of
three human cytomegalovirus strains, Toledo, Towne, and AD169. The low-passage, virulent …

In the present study the electrophysiological characteristics and the proarrhythmic potential
of cisapride and a structurally related drug, mosapride, were compared. In the anesthetized …