Structure of eukaryotic RNA polymerases

…, F Brueckner, C Buchen, GE Damsma… - Annu. Rev …, 2008 - annualreviews.org
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines
that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a …

Scope and limitations of in vivo brain dialysis: a comparison of its application to various neurotransmitter systems

BHC Westerink, G Damsma, H Rollema, JB De Vries… - Life sciences, 1987 - Elsevier
Brain dialysis is rapidly becoming a routine research method with a wide range of applications.
Since 1982 this sampling technique is frequently used as a method to study the in vivo …

Sexual behavior enhances central dopamine transmission in the male rat

JG Pfaus, G Damsma, GG Nomikos, DG Wenkstern… - Brain research, 1990 - Elsevier
Central dopamine transmission was examined in the nucleus accumbens and striatum of
sexually experienced male rats during mating behaviour using in vivo brain microdialysis. …

Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion.

G Damsma, JG Pfaus, D Wenkstern… - Behavioral …, 1992 - psycnet.apa.org
Extracellular concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic
acid (DOPAC) and homovanillic acid (HVA) were examined concurrently, using in vivo …

Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats

JG Pfaus, G Damsma, D Wenkstern, HC Fibiger - Brain research, 1995 - Elsevier
In vivo microdialysis was used to monitor extracellular concentrations of dopamine (DA),
and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the …

Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: an in vivo microdialysis study

J Day, G Damsma, HC Fibiger - Pharmacology Biochemistry and Behavior, 1991 - Elsevier
The possible relationship between behavioral arousal and acetylcholine release in the
striatum, hippocampus and frontal cortex was investigated in rats. In vivo microdialysate …

Mechanism of transcriptional stalling at cisplatin-damaged DNA

GE Damsma, A Alt, F Brueckner, T Carell… - Nature structural & …, 2007 - nature.com
The anticancer drug cisplatin forms 1,2-d(GpG) DNA intrastrand cross-links (cisplatin lesions)
that stall RNA polymerase II (Pol II) and trigger transcription-coupled DNA repair. Here we …

Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif

A Hirtreiter, GE Damsma, ACM Cheung… - Nucleic acids …, 2010 - academic.oup.com
… Spt5 are homologous to the bacterial N -utilization substance G (NusG) factor: the NusG
N-terminal … Precipitated proteins were removed by centrifugation at 14 000 g for 10 minutes and …

[PDF][PDF] Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA

JF Sydow, F Brueckner, ACM Cheung, GE Damsma… - Molecular cell, 2009 - cell.com
… Most efficient cleavage was observed for G,G, A,A, G,U, T,G, A,G, A,C, and G,A mismatches.
… a mismatch that is efficiently extended, we included a G,A mismatch at the end of the hybrid …

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

…, RG MacKenzie, YH Shih, G Damsma… - … of Pharmacology and …, 1995 - ASPET
The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-
[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a …