Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic
functions and mediate pathogenic mechanisms, including the inflammatory response. …

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …

intracellularly, making it ideally suited to modify signaling pathways and gene expression.
The activity of the NAD (P) H oxidases can be modulated by vasoactive hormones and the …

Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase
(COX)]. To examine selectivity of tolerated doses of an inhibitor of the inducible …

Background Patients with arthritis and vascular disease may receive both low-dose aspirin
and other nonsteroidal antiinflammatory drugs. We therefore investigated potential …

Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs
(NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-…

Pathological and clinical studies have suggested that platelets have a role in the pathogenesis
of unstable angina and myocardial infarction. However, the relation of platelet activation …

Circadian timing is generated through a unique series of autoregulatory interactions termed
the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized…

… FitzGerald reports having received consulting fees from NiCox and Merck and research …
FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med …

… Conflict of interest: GA FitzGerald receives financial support for investigator-initiated research
from Bayer, Merck, and Boehringer Ingelheim, all of which manufacture drugs that target …