User profiles for Fred D. Finkelman

Fred Finkelman

University of Cincinnati, Cincinnati Children's
Verified email at ucmail.uc.edu
Cited by 53008

Lymphokine control of in vivo immunoglobulin isotype selection

FD Finkelman, J Holmes, IM Katona… - Annual review of …, 1990 - annualreviews.org
The discovery by Isakson and Vitetta that a T lymphocyte-produced substance could induce
lipopolysaccharide (LPS)-activated murine B lym phocytes to secrete IgG 1 (1) demonstrated …

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

…, D Ruckerl, PC Cook, LH Jones, FD Finkelman… - science, 2011 - science.org
A defining feature of inflammation is the accumulation of innate immune cells in the tissue that
are thought to be recruited from the blood. We reveal that a distinct process exists in which …

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

…, SZ Ben-Sasson, R Seder, FD Finkelman… - The Journal of …, 1990 - rupress.org
T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4)
in response to stimulation on anti-CD3-coated dishes. IL-4 production by such cells is …

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models*

FD Finkelman, T Shea-Donohue… - Annual review of …, 1997 - annualreviews.org
▪ Abstract Studies with rodents infected with Trichinella spiralis, Heligmosomoides polygyrus,
Nippostrongylus brasiliensis, and Trichuris muris have provided considerable information …

[HTML][HTML] IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis

…, KB Madden, SC Morris, M Collins, FD Finkelman - Immunity, 1998 - cell.com
Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus
brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient …

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

…, DJ O'Hearn, X Li, SK Huang, FD Finkelman… - The Journal of …, 1995 - rupress.org
Allergic asthma is characterized by airway hyperresponsiveness and pulmonary eosinophilia,
and may be mediated by T helper (Th) lymphocytes expressing a Th2 cytokine pattern. …

Interleukin‐4‐and interleukin‐13‐mediated host protection against intestinal nematode parasites

FD Finkelman, T Shea‐Donohue… - Immunological …, 2004 - Wiley Online Library
Intestinal worm infections characteristically induce T‐helper 2 cell (Th2) cytokine production.
We reviewed studies performed with mice infected with either of two intestinal nematode …

Anaphylaxis: lessons from mouse models

FD Finkelman - Journal of allergy and clinical immunology, 2007 - Elsevier
Studies with mouse models demonstrate 2 pathways of systemic anaphylaxis: a classic
pathway mediated by IgE, FcɛRI, mast cells, histamine, and platelet-activating factor (PAF) and …

Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite

…, JF Urban Jr, AM Dvorak, FD Finkelman… - The Journal of …, 2004 - rupress.org
Using mice in which the eGfp gene replaced the first exon of the Il4 gene (G4 mice), we
examined production of interleukin (IL)-4 during infection by the intestinal nematode …

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

…, R Ludwig, D Zillikens, F Nimmerjahn, FD Finkelman… - Nature medicine, 2012 - nature.com
Complement is an ancient danger-sensing system that contributes to host defense, immune
surveillance and homeostasis 1 . C5a and its G protein–coupled receptor mediate many of …