In addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer’s …

Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity,
but in ways that are poorly understood. We report here that a form of impulsivity in rats …

Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape emergent …

Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely
linked to neuronal death in Parkinson’s disease. However, the heterogeneity of different co…

Poor decision-making is often observed clinically in the manic syndrome. In normal volunteers,
decision-making has been associated with activation in the ventral prefrontal cortex and …

Previous data suggest that methylphenidate can have variable effects on different cognitive
tasks both within and between individuals. This is thought to be underpinned by inverted U-…

Positron emission tomography (PET) provides dynamic images of the biodistribution of
radioactive tracers in the brain. Through application of the principles of compartmental analysis, …

The ability to assess the distribution and extent of tau pathology in Alzheimer’s disease and
progressive supranuclear palsy in vivo would help to develop biomarkers for these …

Background and Purpose— Perfusion magnetic resonance imaging (pMR) is increasingly
used in acute stroke, but its physiologic significance is still debated. A reasonably good …

Treatment of diaryliodonium salts with cyclotron-produced [18] fluoride in the presence of
potassium carbonate–aminopolyether 2.2. 2 constitutes a new single-step route to no-carrier …