User profiles for Faustino Mollinedo
Faustino MollinedoProfessor, CIB, Consejo Superior de Investigaciones Científicas, Madrid, Spain Verified email at cib.csic.es Cited by 28311 |
Selective Induction of Apoptosis in Cancer Cells by the Ether Lipid ET-18-OCH3 (Edelfosine): Molecular Structure Requirements, Cellular Uptake, and Protection by Bcl-2 and …
The ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH 3 ;
Edelfosine) has been shown to be a rapid inducer of apoptosis in human leukemic cells and …
Edelfosine) has been shown to be a rapid inducer of apoptosis in human leukemic cells and …
Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1
…, SM Nabokina, PA Lazo, F Mollinedo - Journal of leukocyte …, 1999 - academic.oup.com
Syntaxins are major components of vesicle trafficking and their pattern of expression depends
on the cell type. Using reverse transcriptase-polymerase chain reaction (RT-PCR), cloning…
on the cell type. Using reverse transcriptase-polymerase chain reaction (RT-PCR), cloning…
[PDF][PDF] Antitumor alkylphospholipid analogs: a promising and growing family of synthetic cell membrane-targeting molecules for cancer treatment
F Mollinedo - 2014 - digital.csic.es
Antitumor alkylphospholipid analogs (APLs), also known collectively as antitumor lipids (ATLs),
were originally synthesized as synthetic ether-linked metabolically stable analogs of …
were originally synthesized as synthetic ether-linked metabolically stable analogs of …
Microtubules, microtubule-interfering agents and apoptosis
F Mollinedo, C Gajate - Apoptosis, 2003 - Springer
Microtubules are dynamic polymers that play crucial roles in a large number of cellular functions.
Their pivotal role in mitosis makes them a target for the development of anticancer drugs…
Their pivotal role in mitosis makes them a target for the development of anticancer drugs…
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
M Munder, F Mollinedo, J Calafat, J Canchado… - Blood, 2005 - ashpublications.org
The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important
determinant of the inflammatory response of murine macrophages and dendritic cells. …
determinant of the inflammatory response of murine macrophages and dendritic cells. …
Lipid rafts as major platforms for signaling regulation in cancer
F Mollinedo, C Gajate - Advances in biological regulation, 2015 - Elsevier
Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
[HTML][HTML] Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease (∗)
…, D Collado-Escobar, F Mollinedo - Journal of Biological …, 1995 - ASBMB
Protein isoprenylation is a post-translational modification essential for the biological activity
of G-proteins. Inhibition of protein isoprenylation by lovastatin (LOV) induces apoptosis in HL-…
of G-proteins. Inhibition of protein isoprenylation by lovastatin (LOV) induces apoptosis in HL-…
The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
C Gajate, F Mollinedo - Blood, The Journal of the American …, 2001 - ashpublications.org
The antitumor ether lipid ET-18-OCH 3 promotes apoptosis in tumor cells through
intracellular activation of Fas/CD95. Results of this study showed that ET-18-OCH 3 induces …
intracellular activation of Fas/CD95. Results of this study showed that ET-18-OCH 3 induces …
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
C Gajate, F Mollinedo - Blood, 2007 - ashpublications.org
Multiple myeloma (MM) is an incurable B-cell malignancy, requiring new therapeutic strategies.
We have found that synthetic alkyl-lysophospholipids (ALPs) edelfosine and perifosine …
We have found that synthetic alkyl-lysophospholipids (ALPs) edelfosine and perifosine …
Neutrophil degranulation, plasticity, and cancer metastasis
F Mollinedo - Trends in immunology, 2019 - cell.com
Neutrophils are the first responders to inflammation and infection. Recently, an elevated
neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall …
neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall …