… Ishii K, Sheng H, Warner TD, F6rstermann U and Murad F, A … Katsuki S, Arnold WP and Murad
F, Effects of sodium nitroprusside… Arnold WP, Mittal CK, Katsuki S and Murad F, Nitric oxide …

Although cyclic guanosine monophosphate (GMP)'was first described in biological
samplesmore than two decades ago, its role in some physiological processes has only become …

Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological
and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many …

… 5- to 20-fold in incubations of human polymorphonuclear leukocytes preparations (F. Murad
and RT Curnow, unpublished data). The physiological and toxicologicalimplications of these …

… to the agents indicated (Rapoport and Murad, unpublished observation). Protein was … t
Significantly less than non-rubbed tissues exposed to 10 JIM acetylcholine using paired f-…

The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor
has been purified from cultured and native (noncultured) bovine aortic endothelial cells. …

Sodium nitroprusside, nitroglycerin, sodium azide and hydroxylamine increased guanylate
cyclase activity in particulate and/or soluble preparations from various tissues. While sodium …

… The structure was refined by block-matrix least-squares techniques to an R factor (on
3,220 F, I > 2or(I) four-circle diffractometer data) of 0,077, with R = X(F|-|F,)/XļF. The structure …

Endothelium-derived relaxing factor/nitric oxide (EDRF/NO) synthesized by bovine aortic
endothelial cells and subcellular fractions thereof was assayed by its stimulating effect on …

… for 2 min significantly elevated cyclic GMP levels to 168 f 14% of controls (mean f SE, n = 5).
… exposure (105 f 9% of controls; mean f SE, n = 5). Basal cyclic GMP levels were 208 f 70 fmol…