… -activated pacemaker current I(f), and by calcium release from the … f) current was first
described almost 30 years ago (6); fstands for “funny” because of the unusual properties of I(f…

… study on pure heart rate reduction in patients with heart failure and coronary artery
disease was recently published by the BEAUTIFUL (morBidity- mortality EvAlUaTion of the I(f)-…

Low-density lipoproteins (LDL) are atherogenic and represent a strong cardiovascular risk
factor. Therefore, LDL-cholesterol (LDL-C) remains the primary target in lipid lowering therapy…

… f) plays a central role in determining spontaneous activity of the sinus node. Ivabradine, a
selective inhibitor of the I (f… of ambient angina attacks after I (f) channel inhibition. Ivabradine …

Background—Statins improve endothelial function by upregulating endothelial nitric oxide (NO)
production that is mediated by inhibiting the isoprenylation of rho GTPase. Withdrawal of …

Objectives : We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF). Background
: The signal transduction associated with AF is incompletely understood. We hypothesized …

Aims Heart rate was proposed as an emergent cardiovascular (CV) risk factor. Previous
studies have shown associations between increased heart rate and CV risk in various …

Aims Recurrent stroke is a frequent and disabling event. A high heart rate is associated with
cardiovascular outcomes. We investigated the effects of the resting heart rate on …

Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic
and diastolic function in a mouse model of heart failure with preserved ejection fraction | …

Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia.
The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are …