[HTML][HTML] New proline-rich oligopeptides from the venom of African adders: insights into the hypotensive effect of the venoms

…, W Dias-Da-Silva, DV Tambourgi, FV Portaro - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background The snakes from the Bitis genus are some of the most medically important
venomous snakes in sub Saharan Africa, however little is known about the composition and …

[HTML][HTML] Insights into the Hypertensive Effects of Tityus serrulatus Scorpion Venom: Purification of an Angiotensin-Converting Enzyme-Like Peptidase

…, ILM Junqueira de Azevedo, RT Kodama, FV Portaro - Toxins, 2016 - mdpi.com
The number of cases of envenomation by scorpions has grown significantly in Brazil since
2007, with the most severe cases being caused by the Tityus serrulatus scorpion. Although …

[HTML][HTML] In vitro cleavage of bioactive peptides by peptidases from Bothrops jararaca venom and its neutralization by bothropic antivenom produced by Butantan …

…, LK Iwai, IF Lima, D Cajado-Carvalho, FV Portaro - Toxicon, 2017 - Elsevier
In Brazil, envenomation by Bothrops pitvipers is responsible for over 73% of snakebites, and
their venom is a rich source of proteolytic enzymes. Most studies have demonstrated that …

[HTML][HTML] Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in the Tityus serrulatus Venom

…, DC Pimenta, B Duzzi, AK Kuniyoshi, FV Portaro - Toxins, 2019 - mdpi.com
Although omics studies have indicated presence of proteases on the Tityus serrulatus
venom (TsV), little is known about the function of these molecules. The TsV contains …

Neuropeptide Y Family-Degrading Metallopeptidases in the Tityus serrulatus Venom Partially Blocked by Commercial Antivenoms

…, SMT Serrano, DV Tambourgi, FV Portaro - Toxicological …, 2014 - academic.oup.com
Accidents caused by scorpions represent a relevant public health issue in Brazil, being more
recurring than incidents with snakes and spiders. The main species responsible for this …

Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection

…, EN Miyaji, CCF Silva, FV Portaro… - Immunity …, 2018 - Wiley Online Library
Introduction Streptococcus pneumoniae colonizes the nasopharynx of healthy individuals
establishing a commensal relationship with the host. In some conditions, bacteria invade the …

[des-Arg1]-Proctolin: A novel NEP-like enzyme inhibitor identified in Tityus serrulatus venom

…, FC Gozzo, M Fioramonte, DV Tambourgi, FV Portaro… - Peptides, 2016 - Elsevier
The scorpion Tityus serrulatus venom comprises a complex mixture of molecules that
paralyzes and kills preys, especially insects. However, venom components also interact with …

[HTML][HTML] Tityus serrulatus Scorpion Venom: In Vitro Tests and Their Correlation with In Vivo Lethal Dose Assay

…, AF Paes Leme, BA Pauletti, EB Marengo, FV Portaro - Toxins, 2017 - mdpi.com
Scorpion stings are the main cause of human envenomation in Brazil and, for the treatment
of victims, the World Health Organization (WHO) recommends the use of antivenoms. The …

Peptides derived from plasma proteins released by bothropasin, a metalloprotease present in the Bothrops jararaca venom

…, M Palomino, AK Oliveira, LK Iwai, M Faria, FV Portaro - Toxicon, 2017 - Elsevier
Viperid snake venoms contain proteases that affect hemostasis by degrading important proteins
such as those that participate in the coagulation cascade. The Bothrops jararaca venom …

[HTML][HTML] Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model

…, PL de Sá Junior, LI Mambelli, FV Portaro… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Most characterized angiogenic modulators are proteolytic fragments of structural plasma
and/or matrix components. Herein, we have identified a novel anti-angiogenic peptide …