Differential regulation of murine T lymphocyte subsets

FW Fitch, MD McKisic, DW Lancki… - Annual review of …, 1993 - annualreviews.org
Signaling pathways in T lymphocytes have been incompletely charac terized. It is evident
that differences exist among the T cell subsets. We have defined several distinct mechanisms …

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

TF Gajewski, FW Fitch - Journal of immunology (Baltimore, Md …, 1988 - journals.aai.org
A biphasic dose-response curve was observed when the IL-1-dependent HTL clone D10
was exposed to IL-1 plus supernatants from some activated T cell clones but not others. The …

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1. 5: similarity of L3T4 to the human Leu-3/T4 molecule.

…, J Quintans, MR Loken, M Pierres, FW Fitch - … (Baltimore, Md.: 1950 …, 1983 - journals.aai.org
… The method will be described in more detail elsewhere (KA Wall and FW Fitch, manuscript
… MR Loken, and FW Fitch. 1981. Structural differences in cell surface T25 polypeptides from …

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of …

…, AL Glasebrook, FW Fitch - Journal of immunology …, 1980 - journals.aai.org
… Tartof, D., and FW Fitch. Immunologically specific cytolytic activity induced in long-term …
Sanniento, M., AL Glasebrook, and FW Fitch. Cell surface polypeptides of murine T-cell clones …

Blocked Ras Activation in Anergic CD4+ T Cells

PE Fields, TF Gajewski, FW Fitch - Science, 1996 - science.org
T cell anergy is a state of functional unresponsiveness characterized by the inability to
produce interleukin-2 (IL-2) upon T cell receptor stimulation. The mitogen-activated protein …

Changes in heroin self-administration by a rhesus monkey after morphine immunisation

KF Bonese, BH Wainer, FW Fitch, RM Rothberg… - Nature, 1974 - nature.com
WE have investigated in one primate the effect of immunisation against an opiate on the self-administration
of these drugs. Using the rhesus monkey, which will self-administer various …

CD28 costimulation promotes the production of Th2 cytokines.

IC Rulifson, AI Sperling, PE Fields, FW Fitch… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
CD28 ligation augments TCR-mediated proliferation, IL-2 production, and T cell survival.
However, the role of CD28 costimulation in T cell differentiation remains controversial. To …

The road to the discovery of dendritic cells, a tribute to Ralph Steinman

DA Rowley, FW Fitch - Cellular immunology, 2012 - Elsevier
While it was known by the 1960s that lymphocytes mediated adaptive immunity, it was unknown
how antigens stimulated lymphocytes. Between 1967 and 1973, we reported that a rare …

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and …

TF Gajewski, J Joyce, FW Fitch - Journal of immunology (Baltimore …, 1989 - journals.aai.org
Supernatants collected after primary or secondary stimulation of spleen cells contain different
arrays of lymphokines. Primary supernatants from spleen cells stimulated with Con A or …

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1. 5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of …

…, J Kappler, DP Dialynas, FW Fitch - … (Baltimore, Md.: 1950 …, 1983 - journals.aai.org
… limiting dilution, as described by Glasebrmk and Fitch (7), in the presence of 1.25 x IO6 …
and FW Fitch. 1981. Structural differences in cell surface T25 polypeptides from thymocytes …