Corticotropin‐releasing factor (CRF), when administered directly into the CNS, can have
activating properties on behaviour and can enhance behavioural responses to stress. CRF …

CRF in the central nervous system appears to hve activating properties on behavior and to
coordinate behavioral responses to stressors. These behavioral effects of CRF appear to be …

The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting
memories. By combining functional brain imaging and region-specific neuronal inactivation in …

Evidence from animal and human studies suggests that neuropeptide Y (NPY) may be a
potent endogenous anxiolytic. The anatomic structures mediating this action of the peptide …

5-Hydroxytryptamine (5-HT) 2C receptor agonists hold promise for the treatment of obesity.
In this study, we describe the in vitro and in vivo characteristics of lorcaserin [(1R)-8-chloro-2,…

In summary, endogenous CRF has been demonstrated to play an important role in the endocrine
but also autonomic and behavioral responses to a stressor and to mediate some of the …

The synthesis and SAR of a novel 3-benzazepine series of 5-HT 2C agonists is described.
Compound 7d (lorcaserin, APD356) was identified as one of the more potent and selective …

The central nucleus of the amygdala is a CRF-containing limbic brain site which mediates
both fear-like and avoidance behaviors, and intra-amygdala administration of a CRF …

Central administration of neuropeptide Y (NPY) exerts a potent orexigenic effect in rats,
whereas injection of corticotropin-releasing factor (CRF) suppresses food intake. Anatomical …

Background Difelikefalin is a peripherally restricted and selective agonist of kappa opioid
receptors that are considered to be important in modulating pruritus in conditions such as …