Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
S De Flora, A Izzotti, F D'Agostini… - …, 2001 - academic.oup.com
Although smoking cessation is the primary goal for the control of cancer and other smoking-related
diseases, chemoprevention provides a complementary approach applicable to high …
diseases, chemoprevention provides a complementary approach applicable to high …
Multiple genotoxicity biomarkers in fish exposed in situ to polluted river water
S De Flora, L Vigano, F D'agostini, A Camoirano… - Mutation Research …, 1993 - Elsevier
Specimens of rainbow trout (Oncorhynchus mykiss) were either kept in an aquarium under
laboratory conditions or caged in the River Po (Northern Italy), upstream or downstream the …
laboratory conditions or caged in the River Po (Northern Italy), upstream or downstream the …
Effects of Oral Administration of N-Acetyl-l-cysteine: A Multi-Biomarker Study in Smokers
…, A Besarati Nia, S De Flora, F D'Agostini… - … Biomarkers & Prevention, 2002 - AACR
N-Acetyl-l-cysteine (NAC) has been shown to exert cancer-protective mechanisms and effects
in experimental models. We report here the results of a randomized, double-blind, placebo…
in experimental models. We report here the results of a randomized, double-blind, placebo…
Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice
A Izzotti, S Kanitz, F D'Agostini, A Camoirano… - … /Genetic Toxicology and …, 2009 - Elsevier
Endocrine disruptors (EDs) represent a major toxicological and public health issue, and the
xenoestrogen bisphenol A (BPA) has received much attention due to its high production …
xenoestrogen bisphenol A (BPA) has received much attention due to its high production …
Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer
S De Flora, A Izzotti, F D'Agostini… - The American journal of …, 1991 - Elsevier
Our studies provide evidence that thiols, such as N-acetyl-l-cysteine, inhibit both spontaneous
mutations and induced mutations in bacteria, prevent the in vivo formation of carcinogen-…
mutations and induced mutations in bacteria, prevent the in vivo formation of carcinogen-…
Multiple points of intervention in the prevention of cancer and other mutation-related diseases
S De Flora, A Izzotti, F D'Agostini, RM Balansky… - Mutation Research …, 2001 - Elsevier
Multiple points of intervention are the target for dietary and pharmacological interventions
aimed at preventing cancer and other diseases in which mutations in somatic cells play a …
aimed at preventing cancer and other diseases in which mutations in somatic cells play a …
Chemopreventive properties and mechanisms of N‐acetylcysteine. The experimental background
…, RM Balansky, A Albini, F D'Agostini… - Journal of Cellular …, 1995 - Wiley Online Library
The thiol N‐acetylcysteine (NAC), now under clinical trial for cancer chemoprevention both
in Europe (project Euroscan) and in the US (National Cancer Institue), has been shown …
in Europe (project Euroscan) and in the US (National Cancer Institue), has been shown …
Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A–treated rats and formation of DNA adducts in cultured human prostatic cells
…, S La Maestra, A Izzotti, F D'Agostini… - Toxicological …, 2011 - academic.oup.com
Among endocrine disruptors, the xenoestrogen bisphenol A (BPA) deserves particular
attention due to widespread human exposure. Besides hormonal effects, BPA has been …
attention due to widespread human exposure. Besides hormonal effects, BPA has been …
N-acetylcysteine inhibits endothelial cell invasion and angiogenesis.
…, L Masiello, G Fontanini, F D'Agostini… - … ; a journal of technical …, 1999 - europepmc.org
The thiol N-acetylcysteine (NAC) is a chemopreventive agent that acts through a variety of
mechanisms and can prevent in vivo carcinogenesis. We have previously shown that NAC …
mechanisms and can prevent in vivo carcinogenesis. We have previously shown that NAC …
Inhibition of Angiogenesis-driven Kaposi's Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine
A Albini, M Morini, F D'Agostini, N Ferrari, F Campelli… - Cancer research, 2001 - AACR
The thiol N-acetyl-l-cysteine (NAC), an analogue and precursor of reduced glutathione, has
cancer chemopreventive properties attributable to its nucleophilicity, antioxidant activity, and …
cancer chemopreventive properties attributable to its nucleophilicity, antioxidant activity, and …