[HTML][HTML] A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

M Pang, LI Ma, R Gong, E Tolbert, H Mao… - Kidney international, 2010 - Elsevier
Accumulation of both interstitial myofibroblasts and excessive production of extracellular
matrix proteins is a common pathway contributing to chronic kidney disease. In a number of …

Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy

…, J Kothapally, H Mao, E Tolbert… - American Journal …, 2009 - journals.physiology.org
Activation of renal interstitial fibroblasts is critically involved in the development of
tubulointerstitial fibrosis in chronic kidney diseases. In this study, we investigated the effect of …

[HTML][HTML] Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling

N Liu, S He, L Ma, M Ponnusamy, J Tang, E Tolbert… - PloS one, 2013 - journals.plos.org
Background Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs;
however, nonselective inhibition of class I and class II HDACs does not allow a detailed …

Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining Smad7 and phosphatase and tensin homolog expression

…, M Ponnusamy, MV Masucci, E Tolbert… - Journal of the …, 2016 - journals.lww.com
Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine
27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. …

Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis

N Liu, JK Guo, M Pang, E Tolbert… - Journal of the …, 2012 - journals.lww.com
Although enhanced activation of the EGF receptor (EGFR) associates with the development
and progression of renal fibrosis, the mechanisms linking these observations are not …

[HTML][HTML] Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury

J Tang, N Liu, E Tolbert, M Ponnusamy, L Ma… - The American journal of …, 2013 - Elsevier
Severe acute kidney injury (AKI) is frequently accompanied by maladaptive repair and renal
fibrogenesis; however, the molecular mechanisms that mediate these acute and chronic …

[HTML][HTML] Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways

Y Liu, K Rajur, E Tolbert, LD Dworkin - Kidney international, 2000 - Elsevier
Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix
degradation pathways. Background Hepatocyte growth factor (HGF) has been shown to …

[HTML][HTML] Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

…, M Ponnusamy, J Tang, MA Zhuang, E Tolbert… - Kidney international, 2016 - Elsevier
Increased Src activity has been associated with the pathogenesis of renal tumors and some
glomerular diseases, but its role in renal interstitial fibrosis remains elusive. To evaluate this, …

Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 …

R Gong, A Rifai, EM Tolbert, P Biswas… - Journal of the …, 2004 - journals.lww.com
Hepatocyte growth factor (HGF) has been shown to reduce renal injury in a variety of animal
models of chronic renal disease. Suggested mechanisms to explain this action include …

Suramin inhibits renal fibrosis in chronic kidney disease

N Liu, E Tolbert, M Pang, M Ponnusamy… - Journal of the …, 2011 - journals.lww.com
The activation of cytokine and growth factor receptors associates with the development and
progression of renal fibrosis. Suramin is a compound that inhibits the interaction of several …