(−)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271)
is a new high-affinity cannabinoid receptor subtype 1 (CB1 receptor) ligand (K i = 0.46–1.85 …

4-Phenyl-4H-pyrans have been identified as potent and specific IK Ca channel blockers.
Their synthesis and structure–activity relationships are described. A selected derivative, rac-11, …

Early deterioration and death after brain injury is often the result of oedema in the injured and
peri‐lesional tissue. So far, no pharmacotherapy is available that exhibits significant brain …

Many acute and chronic neurodegenerative diseases are characterized by a localized
inflammatory response and constitutive activation of the transcription factors nuclear factor-κB (NF-…

Brain ischemia provoked by stroke or traumatic brain injury induces a massive increase in
neurotransmitter release, in particular of the excitotoxin glutamate. Glutamate triggers a …

BAY 38-7271 is a new high-affinity cannabinoid receptor agonist with strong neuroprotective
efficacy in a rat model of traumatic brain injury (acute subdural hematoma, SDH). In the …

This study characterized the neuroprotective and behavioral effects of (3aS,6aS)-6a-naphtalen-2-ylmethyl-5-methyliden-hexahydro-cyclopenta[c]furan-1-on
(BAY 36-7620), a novel, …

Repinotan is a highly potent 5-HT 1A receptor agonist with strong neuroprotective efficacy
in animal models of middle cerebral artery occlusion and traumatic brain injury. In this study, …

Novel cyclohexadienes have been identified as potent and specific IK Ca -channel blockers.
In this communication we describe their synthesis as well as their chemical and biological …

Traumatic brain injury (TBI) is the most common cause of mortality and morbidity in adults
under 40 years of age in industrialized countries. Worldwide the incidence is increasing, about …