Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible
for more than 500,000 deaths per year worldwide. Here, we report exome and genome …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Lung cancer remains one of the leading causes of cancer-related death in developed countries.
Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to …

Although genomically targeted therapies have improved outcomes for patients with lung
adenocarcinoma, little is known about the genomic alterations that drive squamous cell cancer (…

Purpose The evolution of the epidemiology and mortality of extracorporeal membrane
oxygenation (ECMO) remains unclear. The present study investigates the evolving epidemiology …

Background Chemotherapy is the standard of care for advanced stages of non-small-cell
lung cancer (NSCLC). TG4010 is a targeted immunotherapy based on a poxvirus (modified …

Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations
underlying the pathogenesis of these tumours have not been systematically studied so far. …

We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of
25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas …

BACKGROUND: The advantage of sleeve lobectomy as an alternative to pneumonectomy
for preserving lung function is obvious and among other arguments allows operating on …

Background Genome-wide association studies have identified three chromosomal regions
at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these …