Viscoelastic properties of individual glial cells and neurons in the CNS

…, J Guck, P Janmey, EQ Wei… - Proceedings of the …, 2006 - National Acad Sciences
One hundred fifty years ago glial cells were discovered as a second, non-neuronal, cell type
in the central nervous system. To ascribe a function to these new, enigmatic cells, it was …

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

…, PG Hirrlinger, T Pannicke, EQ Wei… - The FASEB …, 2011 - Wiley Online Library
Increased stiffness of reactive glial cells may impede neurite growth and contribute to the poor
regenerative capabilities of the mammalian central nervous system. We induced reactive …

Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose-and time-dependently protects against focal cerebral ischemia in mice

GL Yu, EQ Wei, SH Zhang, HM Xu, LS Chu, WP Zhang… - Pharmacology, 2005 - karger.com
Our previous studies showed that cysteinyl leukotriene receptor-1 (CysLT 1 ) antagonist
pranlukast has a neuroprotective effect on cerebral ischemia in rats and mice. However, whether …

Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia

…, QQ Xu, Q Zhang, WP Zhang, LH Zhang, EQ Wei - Neuroscience …, 2005 - Elsevier
Erythropoietin (EPO) is a hematopoietic growth factor with tissue-protective properties, and
can protect animals from cerebral ischemic injury. However, the central nervous effects of …

Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor‐1α activation in C6 glioma cells

…, ZQ Ma, WP Zhang, YB Lu, EQ Wei - Journal of Pharmacy …, 2007 - Wiley Online Library
Artemisinin and its analogue dihydroartemisinin exert cytotoxic effects in some kinds of
cancer cell lines. Here we determined whether dihydroartemisinin inhibits the growth and …

Activation of CysLT receptors induces astrocyte proliferation and death after oxygen–glucose deprivation

…, CT Li, WZ Shi, SH Fang, YB Lu, Z Chen, EQ Wei - Glia, 2008 - Wiley Online Library
We recently found that 5‐lipoxygenase (5‐LOX) is activated to produce cysteinyl leukotrienes
(CysLTs), and CysLTs may cause neuronal injury and astrocytosis through activation of …

Autophagy in synaptic development, function, and pathology

DN Shen, LH Zhang, EQ Wei, Y Yang - Neuroscience bulletin, 2015 - Springer
In the nervous system, neurons contact each other to form neuronal circuits and drive
behavior, relying heavily on synaptic connections. The proper development and growth of …

Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats1

…, L CHU, W ZHANG, M WANG, E WEI - Acta pharmacologica …, 2006 - Wiley Online Library
Aim: To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral
ischemia in rats, and the possible relation to 5‐lipoxygenase inhibition. Methods: Transient …

Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors

…, HT Yao, KD Chen, WW Sheng, Z Chen, EQ Wei - Neuroscience …, 2004 - Elsevier
Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators. CysLT receptor 1 (CysLT
1 ) is one of the two CysLT receptors that has been cloned. Although the expression of …

Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H1/H3 receptors

Y Shen, W Hu, Y Fan, H Dai, Q Fu, EQ Wei… - Biochemical …, 2007 - Elsevier
Since the histidine-containing dipeptide carnosine (β-alanyl-l-histidine) is believed to have
many physiological functions in the brain, we investigated the neuroprotective effects of …