Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract

…, V Calderon-Gay, M Germann, E O'Neill… - … of Pharmacology and …, 2008 - ASPET
5-Hydroxytryptamine (serotonin) (5-HT) is a neurotransmitter with both central and peripheral
functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal (GI) …

Metformin is associated with decreased 30-day mortality among nursing home residents infected with SARS-CoV2

MA Lally, P Tsoukas, CW Halladay, E O'Neill… - Journal of the American …, 2021 - Elsevier
Objectives The COVID-19 pandemic presents an urgent need to investigate whether existing
drugs can enhance or even worsen prognosis; metformin, a known mammalian target of …

Discovery of LX2761, a sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor restricted to the intestinal lumen, for the treatment of diabetes

…, D Diaz, S Gopinathan, L Li, E O'Neill… - Journal of Medicinal …, 2017 - ACS Publications
The increasing number of people afflicted with diabetes throughout the world is a major health
issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared …

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders

…, D Bruce, T Smith, L Moran, E O'Neill… - Journal of medicinal …, 2009 - ACS Publications
During nearly a decade of research dedicated to the study of sphingosine signaling pathways,
we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of …

Early toxicology signal generation in the mouse

JA Kramer, E O'Neill, ME Phillips… - Toxicologic …, 2010 - journals.sagepub.com
The rat has been the preferred rodent toxicology species since before regulatory requirements
have been in place, and there exists in the pharmaceutical industry and the regulatory …

Chronic obstructive pulmonary disease and obstructive sleep apnoea overlap: co-existence, co-morbidity, or causality?

E O'Neill, S Ryan, WT McNicholas - Current Opinion in Pulmonary …, 2022 - journals.lww.com
Chronic obstructive pulmonary disease and obstructive sleep... : Current Opinion in Pulmonary
Medicine Chronic obstructive pulmonary disease and obstructive sleep apnoea overlap …

[HTML][HTML] Visual electrophysiology in the assessment of toxicity and deficiency states affecting the visual system

EK O'Neill, R Smith - Eye, 2021 - nature.com
Visual disturbance or visual failure due to toxicity of an ingested substance or a severe
nutritional deficiency can present significant challenges for diagnosis and management, for …

Staphylococcal biofilm: penetration and bioavailability of vancomycin with or without rifampin

KE Daffinee, ET O'Neill, CR Bleick, G Williams… - … and Infectious Disease, 2023 - Elsevier
We measured antibiotic penetration and bioavailability in staphylococcus biofilms using
simulated humanized concentrations of fluorescent vancomycin plus or minus rifampin. …

[HTML][HTML] Electrophysiological assessment of nutritional optic neuropathy: a case report

EK O'Neill, K Mankad, R Bowman… - Documenta …, 2023 - Springer
Purpose To report an unexpectedly asymmetric, progressive nutritional optic neuropathy
associated with vitamin A deficient optic canal hyperostosis in a 15-year-old female with a long …

National trends in hospital, long-term care and outpatient Acinetobacter baumannii resistance rates

HJ Appaneal, E O'Neill, VV Lopes… - Journal of Medical …, 2021 - microbiologyresearch.org
Introduction. Acinetobacter baumannii is a top-priority pathogen of the World Health
Organization (WHO) and the Centers for Disease Control (CDC) due to antibiotic resistance. Gap …