Synthesis and anticonvulsant activity of enaminones. 2. Further structure-activity correlations
…, VA Farrar, JA Moore, EI Tietz… - Journal of medicinal …, 1993 - ACS Publications
This report continues the in-depth evaluationof methyl 4-[(p-chlorophenyl) amino]-6-methyl-2-oxocyclohex-3-en-l-oate,
1 (ADD 196022), and methyl 4-(benzylamino)-6-methyl-2-…
1 (ADD 196022), and methyl 4-(benzylamino)-6-methyl-2-…
[PDF][PDF] Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.
EC Burgard, EI Tietz, TR Neelands… - Molecular …, 1996 - utoledo.edu
The cDNAs encoding a5 and y2L subunit subtypes of the y-aminobutyric acid (GABA) type A
receptor(GABAR) were transfected into L929 cells together with cDNAs encoding either the …
receptor(GABAR) were transfected into L929 cells together with cDNAs encoding either the …
Regional GABA/benzodiazepine receptor/chloride channel coupling after acute and chronic benzodiazepine treatment
EI Tietz, TH Chiu, HC Rosenberg - European journal of pharmacology, 1989 - Elsevier
GABA/benzodiazepine coupling was evaluated in 8 regions of rat brain by the ability of GABA
to stimulate 0.5 nM [ 3 H]flunitrazepam binding. Rats were treated acutely with diazepam (…
to stimulate 0.5 nM [ 3 H]flunitrazepam binding. Rats were treated acutely with diazepam (…
Autoradiographic localization of benzodiazepine receptor downregulation.
EI Tietz, HC Rosenberg, TH Chiu - Journal of Pharmacology and …, 1986 - ASPET
Regional differences in downregulation of brain benzodiazepine receptors were studied using
a quantitative autoradiographic method. Rats were given a 4-week flurazepam treatment …
a quantitative autoradiographic method. Rats were given a 4-week flurazepam treatment …
[HTML][HTML] Transient plasticity of hippocampal CA1 neuron glutamate receptors contributes to benzodiazepine withdrawal-anxiety
BJ Van Sickle, K Xiang, EI Tietz - Neuropsychopharmacology, 2004 - nature.com
Withdrawal from 1-week oral administration of the benzodiazepine (BZ), flurazepam (FZP) is
associated with enhanced AMPA receptor (AMPAR)-mediated and reduced NMDA receptor …
associated with enhanced AMPA receptor (AMPAR)-mediated and reduced NMDA receptor …
Daytime sleepiness and antihistamines
A daytime nap procedure was used to evaluate the daytime sleepiness associated with
antihistamines, as well as to assess their hypnotic potential. Healthy, normal subjects received …
antihistamines, as well as to assess their hypnotic potential. Healthy, normal subjects received …
Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors
DE Earl, EI Tietz - Journal of Pharmacology and Experimental …, 2011 - ASPET
Benzodiazepines (BDZs) depress neuronal excitability via positive allosteric modulation of
inhibitory GABA A receptors (GABA A R). BDZs and other positive GABA A R modulators, …
inhibitory GABA A receptors (GABA A R). BDZs and other positive GABA A R modulators, …
Chronic benzodiazepine administration potentiates high voltage-activated calcium currents in hippocampal CA1 neurons
…, DR Giovannucci, LJ Greenfield, EI Tietz - … of Pharmacology and …, 2008 - ASPET
Signs of physical dependence as a consequence of long-term drug use and a moderate
abuse liability limit benzodiazepine clinical usefulness. Growing evidence suggests a role for …
abuse liability limit benzodiazepine clinical usefulness. Growing evidence suggests a role for …
Tolerance to the anticonvulsant action of benzodiazepines: relationship to decreased receptor density
HC Rosenberg, EI Tietz, TH Chiu - Neuropharmacology, 1985 - Elsevier
Tolerance to the anticonvulsant action of benzodiazepines was studied in rats that had been
treated for 4 weeks with 100–150 mg/kg per day of flurazepam. Previous studies had shown …
treated for 4 weeks with 100–150 mg/kg per day of flurazepam. Previous studies had shown …
Immunocytochemical detection of regional protein changes in rat brain sections using computer-assisted image analysis.
X Huang, S Chen, EI Tietz - Journal of Histochemistry & …, 1996 - journals.sagepub.com
We used several approaches to assess the reliability and sensitivity of computer-assisted
densitometry to detect regional changes in tissue antigen content as a function of …
densitometry to detect regional changes in tissue antigen content as a function of …