“Enabling Occupation II is a necessary and very valuable book for occupational therapy
students and for practicing occupational therapists. It promotes the concept of enabling …

Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas. …

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes
to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and …

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient
efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX…

Here we report a comprehensive characterization of our recently developed inhibitor MM-401
that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically inhibit …

Good Intentions OverRuled is about empowerment; so it is also about power. This book shows
how power is exerted in the routine organizational processes that determine what can be …

The prevalence of asthma has increased in recent years, and is characterized by airway
hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-…

Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase, and
targeting the MLL1 enzymatic activity has been proposed as a novel therapeutic strategy for …

Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL)
1 , and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs 2 . Yet …

There is general agreement that mental health is a foundation for living well. Unfortunately,
approximately 20% of people around the world will experience a mental health issue at some …