Activation of TLRs (Toll-like receptors) induces gene expression of proteins involved in the
immune system response. TLR4 has been implicated in the development and progression of …

Objective We investigated the effects of high-fat diet-induced obesity on vascular
proinflammatory factors and oxidative stress on endothelium-dependent relaxation of the aorta. …

Besides the effects on peripheral energy homeostasis, insulin also has an important role in
ovarian function. Obesity has a negative effect on fertility, and may play a role in the …

The perivascular adipose tissue (PVAT) releases a variety of factors that affect vascular
function. PVAT in the thoracic aorta shares characteristics with the brown adipose tissue, …

Testosterone has been added to hormone replacement therapy to treat sexual dysfunction
in postmenopausal women. Whereas estrogen has been associated with vascular protection, …

Increasing scientific interest has been directed to sex as a biological and decisive factor on
several diseases. Several different mechanisms orchestrate vascular function, as well as …

Human life span expectancy has increased, and aging affects the organism in several ways,
leading, for example, to an increased risk of cardiovascular diseases. Age-adjusted …

Maternal malnutrition is known to impair fetal growth and predispose to the development of
hypertension and type 2 diabetes. Recently, studies have demonstrated that intrauterine …

Background Sepsis is an emergency medical condition that can lead to death and it is defined
as a life-threatening organ dysfunction caused by immune dysregulation in response to …

The kallikrein-kinin and renin-angiotensin systems interact at multiple levels. In the present
study, we tested the hypothesis that the B1 kinin receptor (B1R) contributes to vascular …