User profiles for Edward R. Siuda
 | Edward SiudaJanssen Pharmaceuticals Verified email at its.jnj.com Cited by 4009 |
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics
Successful integration of advanced semiconductor devices with biological systems will
accelerate basic scientific discoveries and their translation into clinical technologies. In …
accelerate basic scientific discoveries and their translation into clinical technologies. In …
[PDF][PDF] CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety
The locus coeruleus noradrenergic (LC-NE) system is one of the first systems engaged
following a stressful event. While numerous groups have demonstrated that LC-NE neurons are …
following a stressful event. While numerous groups have demonstrated that LC-NE neurons are …
Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior
10.7554/eLife.18247.001 Increased tonic activity of locus coeruleus noradrenergic (LC-NE)
neurons induces anxiety-like and aversive behavior. While some information is known about …
neurons induces anxiety-like and aversive behavior. While some information is known about …
[PDF][PDF] Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins
Transmembrane AMPA receptor regulatory proteins (TARPs) and cornichon proteins (CNIH-2/3)
independently modulate AMPA receptor trafficking and gating. However, the potential …
independently modulate AMPA receptor trafficking and gating. However, the potential …
New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors
AMPA-type glutamate receptors (GluRs) mediate most excitatory signaling in the brain and
are composed of GluR principal subunits and transmembrane AMPA receptor regulatory …
are composed of GluR principal subunits and transmembrane AMPA receptor regulatory …
[PDF][PDF] Spatiotemporal control of opioid signaling and behavior
Optogenetics is now a widely accepted tool for spatiotemporal manipulation of neuronal activity.
However, a majority of optogenetic approaches use binary on/off control schemes. Here, …
However, a majority of optogenetic approaches use binary on/off control schemes. Here, …
Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics
ER Siuda, R Carr III, DH Rominger, JD Violin - Current opinion in …, 2017 - Elsevier
Highlights • Biased MOR ligands discovered using empirical, rational and natural product
approaches. • Biased MOR ligands produce analgesia with fewer side effects in mice and …
approaches. • Biased MOR ligands produce analgesia with fewer side effects in mice and …
[HTML][HTML] AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
AS Kato, ER Siuda, ES Nisenbaum, DS Bredt - Neuron, 2008 - cell.com
AMPA-type glutamate receptors (GluRs) play major roles in excitatory synaptic transmission.
Neuronal AMPA receptors comprise GluR subunits and transmembrane AMPA receptor …
Neuronal AMPA receptors comprise GluR subunits and transmembrane AMPA receptor …
[HTML][HTML] Optodynamic simulation of β-adrenergic receptor signalling
Optogenetics has provided a revolutionary approach to dissecting biological phenomena.
However, the generation and use of optically active GPCRs in these contexts is limited and it …
However, the generation and use of optically active GPCRs in these contexts is limited and it …
Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics
Objective. Wireless control and power harvesting systems that operate injectable, cellular-scale
optoelectronic components provide important demonstrated capabilities in …
optoelectronic components provide important demonstrated capabilities in …