Proteasome inhibitors: a novel class of potent and effective antitumor agents

J Adams, VJ Palombella, EA Sausville, J Johnson… - Cancer research, 1999 - AACR
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins
involved in cell cycle control and tumor growth. Dysregulating the degradation of such …

A gene expression database for the molecular pharmacology of cancer

…, DT Andrews, DA Scudiero, MB Eisen, EA Sausville… - Nature …, 2000 - nature.com
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …

An information-intensive approach to the molecular pharmacology of cancer

…, WW Van Osdol, AP Monks, DA Scudiero, EA Sausville… - Science, 1997 - science.org
Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …

Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.

…, EA Sausville, KL Duncan, ED Korn - Journal of Biological …, 1994 - Elsevier
Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, Jaspis johnstoni,
has both fungicidal and antiproliferative activity. We now report that this peptide is a potent …

Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth …

…, S Fan, M Mutoh, DA Scudiero, A Monks, EA Sausville… - Cancer research, 1997 - AACR
In the present study, we report the characterization of the p53 tumor suppressor pathway in
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …

Issues and progress with protein kinase inhibitors for cancer treatment

J Dancey, EA Sausville - Nature reviews Drug discovery, 2003 - nature.com
Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 such …

Flavopiridol Induces G1 Arrest with Inhibition of Cyclin-dependent Kinase (CDK) 2 and CDK4 in Human Breast Carcinoma Cells

BA Carlson, MM Dubay, EA Sausville, L Brizuela… - Cancer research, 1996 - AACR
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle
progression in either G 1 or G 2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor. In …

[HTML][HTML] The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

…, L Yu, JK Schwarz, J Gales, EA Sausville… - Journal of Biological …, 2000 - ASBMB
A checkpoint operating in the G 2 phase of the cell cycle prevents entry into mitosis in the
presence of DNA damage. UCN-01, a protein kinase inhibitor currently undergoing clinical …

Preclinical and clinical development of cyclin-dependent kinase modulators

AM Senderowicz, EA Sausville - Journal of the National Cancer …, 2000 - academic.oup.com
In the last decade, the discovery and cloning of the cyclin-dependent kinases (cdks), key
regulators of cell cycle progression, have led to the identification of novel modulators of cdk …

A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in the initial treatment of mycosis fungoides

…, MJ Anderson, EA Sausville - … England Journal of …, 1989 - Mass Medical Soc
Mycosis fungoides is a T-cell lymphoma that arises in the skin and progresses at highly
variable rates. Nonrandomized studies have suggested that early aggressive therapy may …