User profiles for Edilio Borroni
Edilio BorroniHoffmann-La Roche Ltd. Verified email at roche.com Cited by 6161 |
[HTML][HTML] Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
…, BI Giasson, L Ozmen, E Borroni… - The Journal of …, 2002 - Am Soc Clin Investig
The pathological modifications of α-synuclein (αS) in Parkinson disease and related diseases
are poorly understood. We have detected misfolded αS in situ based on the proteinase K …
are poorly understood. We have detected misfolded αS in situ based on the proteinase K …
Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid …
Importance Tau positron emission tomography (PET) tracers have proven useful for the
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …
Trace amine-associated receptor 1 modulates dopaminergic activity
The recent identification of the trace amine-associated receptor (TAAR)1 provides an
opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-…
opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-…
Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study
…, D Alberati, M Martin-Facklam, E Borroni… - JAMA …, 2014 - jamanetwork.com
Importance In schizophrenia, the severity of negative symptoms is a key predictor of long-term
disability. Deficient signaling through theN-methyl-D-aspartate receptor is hypothesized to …
disability. Deficient signaling through theN-methyl-D-aspartate receptor is hypothesized to …
Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a …
C Riemer, E Borroni, B Levet-Trafit… - Journal of medicinal …, 2003 - ACS Publications
A small series of aryl pyridyl sulfones has been prepared and investigated for its 5-HT 6 receptor
binding properties. Thereof, pyrrolidinyl derivative 11 proved to be a very potent (pK i 9) …
binding properties. Thereof, pyrrolidinyl derivative 11 proved to be a very potent (pK i 9) …
Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice
…, T Ballard, V Müller, M Woolley, L Ozmen, E Borroni… - Neurobiology of …, 2007 - Elsevier
Intraneuronal α-synuclein (αSYN) inclusions constitute the hallmark lesions of a number of
neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. …
neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. …
RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
TM Ballard, F Knoflach, E Prinssen, E Borroni… - …, 2009 - Springer
Rationale GABA A α5 subunit-containing receptors are primarily expressed in the hippocampus
and their role in learning and memory has been demonstrated recently by both genetic …
and their role in learning and memory has been demonstrated recently by both genetic …
Biomarker-based prediction of longitudinal tau positron emission tomography in Alzheimer disease
Importance There is currently no consensus as to which biomarkers best predict longitudinal
tau accumulation at different clinical stages of Alzheimer disease (AD). Objective To …
tau accumulation at different clinical stages of Alzheimer disease (AD). Objective To …
Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl] …
…, D Alberati, M Bender, E Borroni… - Journal of medicinal …, 2010 - ACS Publications
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia.
Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine …
Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine …
Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides.
A Bourson, E Borroni, RH Austin, FJJ Monsma… - … of Pharmacology and …, 1995 - ASPET
The purpose of the present study was to determine possible physiological functions of the 5-ht6
receptor using antisense oligonucleotides (AOs) in male rats. Repeated …
receptor using antisense oligonucleotides (AOs) in male rats. Repeated …