User profiles for Edilio Borroni

Edilio Borroni

Hoffmann-La Roche Ltd.
Verified email at roche.com
Cited by 6161

[HTML][HTML] Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

…, BI Giasson, L Ozmen, E Borroni… - The Journal of …, 2002 - Am Soc Clin Investig
The pathological modifications of α-synuclein (αS) in Parkinson disease and related diseases
are poorly understood. We have detected misfolded αS in situ based on the proteinase K …

Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid …

…, L Iaccarino, R La Joie, S Baker, E Borroni… - JAMA …, 2021 - jamanetwork.com
Importance Tau positron emission tomography (PET) tracers have proven useful for the
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …

Trace amine-associated receptor 1 modulates dopaminergic activity

…, H Bluethmann, B Bettler, JG Wettstein, E Borroni… - … of Pharmacology and …, 2008 - ASPET
The recent identification of the trace amine-associated receptor (TAAR)1 provides an
opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-…

Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study

…, D Alberati, M Martin-Facklam, E Borroni… - JAMA …, 2014 - jamanetwork.com
Importance In schizophrenia, the severity of negative symptoms is a key predictor of long-term
disability. Deficient signaling through theN-methyl-D-aspartate receptor is hypothesized to …

Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex:  Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a …

C Riemer, E Borroni, B Levet-Trafit… - Journal of medicinal …, 2003 - ACS Publications
A small series of aryl pyridyl sulfones has been prepared and investigated for its 5-HT 6 receptor
binding properties. Thereof, pyrrolidinyl derivative 11 proved to be a very potent (pK i 9) …

Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

…, T Ballard, V Müller, M Woolley, L Ozmen, E Borroni… - Neurobiology of …, 2007 - Elsevier
Intraneuronal α-synuclein (αSYN) inclusions constitute the hallmark lesions of a number of
neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. …

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

TM Ballard, F Knoflach, E Prinssen, E Borroni… - …, 2009 - Springer
Rationale GABA A α5 subunit-containing receptors are primarily expressed in the hippocampus
and their role in learning and memory has been demonstrated recently by both genetic …

Biomarker-based prediction of longitudinal tau positron emission tomography in Alzheimer disease

…, O Strandberg, JW Vogel, AP Binette, E Borroni… - JAMA …, 2022 - jamanetwork.com
Importance There is currently no consensus as to which biomarkers best predict longitudinal
tau accumulation at different clinical stages of Alzheimer disease (AD). Objective To …

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl] …

…, D Alberati, M Bender, E Borroni… - Journal of medicinal …, 2010 - ACS Publications
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia.
Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine …

Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides.

A Bourson, E Borroni, RH Austin, FJJ Monsma… - … of Pharmacology and …, 1995 - ASPET
The purpose of the present study was to determine possible physiological functions of the 5-ht6
receptor using antisense oligonucleotides (AOs) in male rats. Repeated …