Early studies revealed that cigarette smoke promotes gastric cancer growth through the
induction of cyclooxygenase-2 (COX-2). Nicotine, one of the active ingredients in cigarette smoke…

Using the non-ulcerogenic doses of dexamethasone, we explored the action of glucocorticoids
on ulcer healing and its relationship with angiogenic factors in the gastric mucosa. We …

Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco, has been implicated
as playing a role in carcinogenesis. Our previous study showed that passive cigarette …

Background/Aims: Patients with peptic ulcer diseases have a high prevalence of coexisting
chronic gastritis. The mechanism of how gastritis leads to gastric ulcer formation is yet to be …

4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the tobacco-specific nitrosamine,
induces lung cancer in all animal species tested and is thought to contribute significantly …

Although the ulcerogenic action of corticosteroids in the stomach is controversial, its action
on ulcer healing has not been defined. In this study, we used non-ulcerogenic doses of …

Both chronic ulcerative colitis and smoking are associated with colorectal cancer in humans.
In the present study, we investigated the effects of cigarette smoke (CS) exposure on …

The association between cigarette smoking and peptic ulcer diseases has been well established.
Ornithine decarboxylase (ODC) is crucial for the gastroprotective and mucosal growth …

Morphine pretreatment protects against stress-induced gastric ulceration, however, the exact
mechanism is still undefined. Interestingly, the effect of morphine on ulcer healing has not …

Nicotine is one of the most representative components in cigarette smoke leading to gastric
ulceration. Both ornithine decarboxylase and potassium ion (K + ) channels are essential for …