User profiles for E. Vallender

Eric Vallender

University of Mississippi Medical Center
Verified email at umc.edu
Cited by 7560

Positive selection on the human genome

EJ Vallender, BT Lahn - Human Molecular Genetics, 2004 - academic.oup.com
Positive selection has undoubtedly played a critical role in the evolution of Homo sapiens. Of
the many phenotypic traits that define our species—notably the enormous brain, advanced …

Evolutionary and biomedical insights from the rhesus macaque genome

…, HA Lawson, A Marklein, R Nielsen, EJ Vallender… - science, 2007 - science.org
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …

Genetic basis of human brain evolution

EJ Vallender, N Mekel-Bobrov, BT Lahn - Trends in neurosciences, 2008 - cell.com
Human evolution is characterized by a rapid increase in brain size and complexity. Decades
of research have made important strides in identifying anatomical and physiological …

Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans

PD Evans, SL Gilbert, N Mekel-Bobrov, EJ Vallender… - science, 2005 - science.org
The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong
positive selection in the human evolutionary lineage. We show that one genetic variant of …

Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens

N Mekel-Bobrov, SL Gilbert, PD Evans, EJ Vallender… - Science, 2005 - science.org
The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of
brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong …

[HTML][HTML] Accelerated evolution of nervous system genes in the origin of Homo sapiens

S Dorus, EJ Vallender, PD Evans, JR Anderson… - Cell, 2004 - cell.com
Human evolution is characterized by a dramatic increase in brain size and complexity. To
probe its genetic basis, we examined the evolution of genes involved in diverse aspects of …

How mammalian sex chromosomes acquired their peculiar gene content

EJ Vallender, BT Lahn - BioEssays, 2004 - Wiley Online Library
It has become increasingly evident that gene content of the sex chromosomes is markedly
different from that of the autosomes. Both sex chromosomes appear enriched for genes …

[PDF][PDF] Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque

…, SV Westmoreland, KG Mansfield, EJ Vallender… - Cell host & …, 2015 - cell.com
The gut microbiome is widely studied by fecal sampling, but the extent to which stool reflects
the commensal composition at intestinal sites is poorly understood. We investigated this …

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans

PD Evans, JR Anderson, EJ Vallender… - Human Molecular …, 2004 - academic.oup.com
A prominent trend in the evolution of humans is the progressive enlargement of the cerebral
cortex. The ASPM (Abnormal spindle-like microcephaly associated) gene has the potential …

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage

…, N Mekel-Bobrov, EJ Vallender… - Proceedings of the …, 2006 - National Acad Sciences
At the center of the debate on the emergence of modern humans and their spread throughout
the globe is the question of whether archaic Homo lineages contributed to the modern …