Wortmannin, a microbial product inhibitor of myosin light chain kinase.
…, S Kakita, I Takahashi, K Kawahara, E Tsukuda… - Journal of Biological …, 1992 - ASBMB
We have found that a fungal strain, Talaromyces wortmannin KY12420, produces a potent
inhibitor of smooth muscle myosin light chain kinase (MLCK). This active product, designated …
inhibitor of smooth muscle myosin light chain kinase (MLCK). This active product, designated …
Production of acrolein from glycerol over silica-supported heteropoly acids
E Tsukuda, S Sato, R Takahashi, T Sodesawa - Catalysis Communications, 2007 - Elsevier
Dehydration of glycerol to produce acrolein was performed over several solid acids. Supported
heteropoly acids were effective as a catalyst for the dehydration of glycerol. The catalytic …
heteropoly acids were effective as a catalyst for the dehydration of glycerol. The catalytic …
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur
S Nakanishi, S Toki, Y Saitoh, E Tsukuda… - Bioscience …, 1995 - academic.oup.com
Dehydroaltenusin, cyciooctasulfur, atrovenetinone, and altenusin were isolated from the
culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticil/us subsp. …
culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticil/us subsp. …
RES-701-1, A NOVEL AND SELECTIVE ENDOTHELIN TYPE B RECEPTOR ANTAGONIST PRODUCED BY Streptomyces sp. RE-701 I. CHARACTERIZATION OF …
Y Morishita, S Chiba, E Tsukuda, T Tanaka… - The Journal of …, 1994 - jstage.jst.go.jp
RES-701-1, a novel cyclic peptide endothelin antagonist, wasisolated from the culture broth
of Streptomyces sp. RE-701. RES-701-1 selectively inhibited the ET-1 binding to type B …
of Streptomyces sp. RE-701. RES-701-1 selectively inhibited the ET-1 binding to type B …
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure− activity relationship, and biological effects of a new …
…, NA Lokker, JC Yu, J Irie, E Tsukuda… - Journal of medicinal …, 2002 - ACS Publications
… The widely used synthetic route to the thioureas was condensation of 1 with commercially
available isothiocyanates described in Scheme 5 (method E). Additionally, isothiocyanates …
available isothiocyanates described in Scheme 5 (method E). Additionally, isothiocyanates …
RES-701-2,-3 and-4, novel and selective endothelin type B receptor antagonists produced by Streptomyces sp. I. Taxonomy of producing strains, fermentation …
…, K OCHIAI, T TANAKA, E TSUKUDA… - The Journal of …, 1995 - jstage.jst.go.jp
1214 THE JOURNAL OF ANTIBIOTICS incubated at 28 C for 4days on a rotary shaker (200
rpm). Forty ml of the above seed culture were added to a 2-liter Erlenmeyer flask containing …
rpm). Forty ml of the above seed culture were added to a 2-liter Erlenmeyer flask containing …
[PDF][PDF] RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin.
T Tanaka, E Tsukuda, M Nozawa, H Nonaka… - Molecular …, 1994 - Citeseer
The unique cyclic peptide designated RES-701-1 blocked the binding of 125l-labeled
endothelin(ET)-1 to bovine cerebellar membranes. ETB receptors are predominant in bovine …
endothelin(ET)-1 to bovine cerebellar membranes. ETB receptors are predominant in bovine …
Surface fault ruptures on the northwest coast of Awaji island associated with the Hyogo-ken Nanbu earthquake of 1995, Japan; Hyogoken nanbu jishin ni tomonatte …
…, R Imura, K Shimokawa, K Okumura, E Tsukuda… - Zisin (Journal of the …, 1996 - osti.gov
The NW coast of Awaji Island was surveyed to study the feature of earthquake faults caused
by the Hyogo-ken Nanbu Earthquake and the relation between the earthquake faults and …
by the Hyogo-ken Nanbu Earthquake and the relation between the earthquake faults and …
RES-1214-1 and-2, novel non-peptidic endothelin type A receptor antagonists produced by Pestalotiopsis sp.
…, Y Aotani, K Shinoda, T Tanaka, E TSUKUDA… - The Journal of …, 1995 - jstage.jst.go.jp
ET-1 binding assays were performed as described previously5). Briefly, bovine cerebellum
membranes were used for a source of ETBreceptor. Bovine lung membranes, which are …
membranes were used for a source of ETBreceptor. Bovine lung membranes, which are …
Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following …
…, S Oda, Y Nomoto, K Matsuno, S Ide, E Tsukuda… - … of Pharmacology and …, 2001 - ASPET
Exaggerated or inappropriate signaling by the platelet-derived growth factor receptor (PDGFR)
tyrosine kinase has been implicated in a wide variety of diseases. Thus, a series of …
tyrosine kinase has been implicated in a wide variety of diseases. Thus, a series of …