User profiles for E. Pefani

Dafni Eleftheria Pefani

University of Patras
Verified email at upatras.gr
Cited by 1005

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study

…, MI Hermanns, V Grossmann, E Pefani… - Blood, The Journal …, 2016 - ashpublications.org
Mean platelet volume (MPV), a measure of platelet size, is a potential biological marker of
platelet function. To date, a comprehensive analysis including known genetic and nongenetic …

Integrating the DNA damage and protein stress responses during cancer development and treatment

VG Gorgoulis, DE Pefani, IS Pateras… - The Journal of …, 2018 - Wiley Online Library
During evolution, cells have developed a wide spectrum of stress response modules to
ensure homeostasis. The genome and proteome damage response pathways constitute the …

Surface topography and site stratigraphy effects on the seismic response of a slope in the Achaia-Ilia (Greece) 2008 Mw6. 4 earthquake

P Pelekis, A Batilas, E Pefani, V Vlachakis… - Soil Dynamics and …, 2017 - Elsevier
Following an overview of the state of knowledge on the effects of slope topography on the
seismic ground response, the results of numerical analyses of the response of a 28 slope, with …

Hippo pathway and protection of genome stability in response to DNA damage

DE Pefani, E O'Neill - The FEBS journal, 2016 - Wiley Online Library
The integrity of DNA is constantly challenged by exposure to the damaging effects of chemical
and physical agents. Elucidating the cellular mechanisms that maintain genomic integrity …

Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia

E Pefani, N Panoskaltsis, A Mantalaris… - IEEE Transactions …, 2014 - ieeexplore.ieee.org
… 4 it will convert the expression to an Emax PD model. The effect, j, calculated by the PD model
is the percentage of cells which react with the drug j and are killed. This effect is multiplied …

A systematic framework for the design, simulation and optimization of personalized healthcare: making and healing blood

M Fuentes-Garí, E Velliou, R Misener, E Pefani… - Computers & Chemical …, 2015 - Elsevier
We review the key building blocks of a design framework for modeling and optimizing biomedical
systems under development in the Biological Systems Engineering Laboratory and the …

[PDF][PDF] TGF-β targets the hippo pathway scaffold RASSF1A to facilitate YAP/SMAD2 nuclear translocation

DE Pefani, D Pankova, AG Abraham, AM Grawenda… - Molecular cell, 2016 - cell.com
… RASSF1A is proteasome-mediated (Figures 1E and 1F). Moreover, addition of TGF-bRI
kinase inhibitor II (E-616451) could maintain RASSF1A stability (Figure 1E). To verify that TGF-b-…

Design of optimal patient-specific chemotherapy protocols for the treatment of acute myeloid leukemia (AML)

E Pefani, N Panoskaltsis, A Mantalaris… - Computers & chemical …, 2013 - Elsevier
… M,j ) as is calculated by the PK model,(4) e f f e c t , j = E max , j ⋅ C M , j s l o p e , j E 50 , j +
C M , j s l o p e , j where E max,j , E 50,j and slope are the PD parameters that depend on the …

Ribosomal DNA and the nucleolus at the heart of aging

E Kasselimi, DE Pefani, S Taraviras… - Trends in Biochemical …, 2022 - cell.com
The rRNA genes [ribosomal DNA (rDNA)] are organized in a prominent nuclear compartment,
the nucleolus. It is now well established that the nucleolus functions beyond ribosome …

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche

C Kyrousi, M Arbi, GA Pilz, DE Pefani… - …, 2015 - journals.biologists.com
… et al., 2011), and its mRNA and protein expression are restricted to the choroid plexus and
cortical hem epithelium during early brain development (Pefani et al., 2011). Later studies …